UniProt Accession

 T2FA_MOUSE; Q3THK3; Q8R5B7 

Genbank Protein ID

 AK168236; AK168243; CH466537; BC023081; BC031123 

Genbank Nucleotide ID

 BAE40186.1; BAE40193.1; EDL38221.1; AAH23081.1; AAH31123.1 

Protein Name

 General transcription factor IIF subunit 1 

Protein Synonyms/Alias

 Transcription initiation factor IIF subunit alpha; TFIIF-alpha 

Gene Name

 Gtf2f1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
407	TLRAAASKLEQGKRT	acetylation	[1, 2]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 217 217 Phosphoserine.
 MOD_RES 218 218 Phosphoserine.
 MOD_RES 221 221 Phosphoserine.
 MOD_RES 224 224 Phosphoserine.
 MOD_RES 331 331 Phosphothreonine.
 MOD_RES 377 377 Phosphoserine (By similarity).
 MOD_RES 380 380 Phosphoserine (By similarity).
 MOD_RES 381 381 Phosphoserine (By similarity).
 MOD_RES 385 385 Phosphoserine (By similarity).
 MOD_RES 389 389 Phosphothreonine (By similarity).
 MOD_RES 391 391 Phosphoserine (By similarity).
 MOD_RES 407 407 N6-acetyllysine (By similarity).
 MOD_RES 431 431 Phosphoserine (By similarity).
 MOD_RES 433 433 Phosphoserine (By similarity).
 MOD_RES 436 436 Phosphoserine (By similarity).
 MOD_RES 437 437 Phosphothreonine (By similarity).
 MOD_RES 440 440 Phosphoserine (By similarity).  

Keyword

 Acetylation; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 508 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:Compara.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003824; F:catalytic activity; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0019211; F:phosphatase activator activity; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0009615; P:response to virus; IEA:Compara.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; IEA:InterPro. 

Interpro

 IPR008851; TFIIF-alpha.
 IPR011039; TFIIF_interaction.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF05793; TFIIF_alpha 

SMART

  

PROSITE

  

PRINTS