| Tag | Content |
|---|
| CPLM ID | CPLM-011439 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Chromatin structure-remodeling complex protein RSC3 |
Protein Synonyms/Alias | Remodel the structure of chromatin complex subunit 3 |
Gene Name | RSC3 |
Gene Synonyms/Alias | YDR303C; D9740.13 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 383 | NSILPILKPKRLLPI | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is required for transcription of ribosomal protein genes and genes involved in the integrity of the cell wall, and also for proper metaphase progression. Together with HTL1, LDB7, NPL6, RSC30 components, defines a fungal-specific module within the RSC complex that plays a role in many cellular functions including the maintenance of cell wall integrity. |
Sequence Annotation | DNA_BIND 14 42 Zn(2)-C6 fungal-type.
MOD_RES 95 95 Phosphoserine.
MOD_RES 236 236 Phosphoserine. |
Keyword | Chromatin regulator; Complete proteome; Direct protein sequencing; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 885 AA |
Protein Sequence | MDIRGRKMKK PPACVQCRKR KIGCDRVKPI CGNCMKHNKM DCFYPDVPGQ YVPSSSSSSN 60
TRQVANGPYL NSYYASRRVS KETAALLQKN PELASLEQIR EYNTRLQLLN AQNQLNNRSS 120
AANATLNQQH TQYIPKSVPS LESKPVTSAN ESSTPLNWVQ GPAIFHMLTS PYTQDEIINH 180
EMNFLKGRLL ELQEITGKKI TGVNLDLKQD SSAQMQSSHS NRNQEEFLTI KKRKLSEDGV 240
TDGDGKPIPE SERRPHLNEF KDLDPQFLDT NKVFNVFNSA ISEEGRNRLW LLPKNINKSS 300
IFQIQYLIER DPFLFKFFND LNILIETQFN GPLHDLVASR NSIERNSGIS QILKFPSQSI 360
TQTLINKYLS TITETNSILP ILKPKRLLPI VEQLFPSNTI NKPNSKDFET IFQVFSVTND 420
QLLNLGFITL CLLILFESLN STVLIPLRDD EHLQLFNVLF NYLPLLKSNL TTLRFEIEKR 480
SMCNIETLRF ISLWKYYQFV MDTSSSSSFV IDYDEDMHMA CLLSLNHETQ NQSHILTWNF 540
IFKNYCWRHL FLGQLPLLMS EPFTNSTPII DPLLNNDFEL IDFEVNLMKY LQSKDQQLSI 600
DKIIQLIKLL KNKNIEVSQG CLTTPSIINN IMDSLIYRNS MLYLNFYLLL QFETLKNYAK 660
FNEILEDFLE LSRETLFFVF SNLANIKFAG HEFTFINKSI VVLQTLVLML LALYQRSFDS 720
SKRTNDANEI SEQTDIHSNN DNSKRIKNKN VIHLIINKIA MLLSDYTKNC KKQNKLIENL 780
IIKIKTISKY IKNLEENKVT TSADSNYSIN NGFSGISAEQ LIKLNHELSK ISESLIKTDF 840
YEQRKNSTVS NGVLGAAAPV DSDANSDTFG LTKENFNEVF EAIRS 885 |
Gene Ontology | GO:0016586; C:RSC complex; IDA:UniProtKB. GO:0043565; F:sequence-specific DNA binding; IDA:SGD. GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IEA:InterPro. GO:0008270; F:zinc ion binding; NAS:UniProtKB. GO:0043044; P:ATP-dependent chromatin remodeling; IDA:SGD. GO:0000082; P:G1/S transition of mitotic cell cycle; IMP:SGD. GO:0000086; P:G2/M transition of mitotic cell cycle; IMP:SGD. GO:0006337; P:nucleosome disassembly; IDA:SGD. GO:0016584; P:nucleosome positioning; IMP:SGD. GO:0033262; P:regulation of nuclear cell cycle DNA replication; IGI:SGD. GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEA:GOC. GO:0006368; P:transcription elongation from RNA polymerase II promoter; IDA:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |