UniProt Accession

 MCFD2_HUMAN; Q8NI22; A8K7W2; D6W5A9; E9PD95; Q53SS3; Q68D61; Q8N3M5 

Genbank Protein ID

 AF475284; AF537214; AK292127; AL833900; CR749562; AC016722; AC093732; CH471053; CH471053; CH471053; CH471053; BC037845; BC040357 

Genbank Nucleotide ID

 AAM28465.1; AAP23162.1; BAF84816.1; CAD38756.1; CAH18359.1; AAY15013.1; EAX00230.1; EAX00231.1; EAX00232.1; EAX00233.1; AAH37845.1; AAH40357.1 

Protein Name

 Multiple coagulation factor deficiency protein 2 

Protein Synonyms/Alias

 Neural stem cell-derived neuronal survival protein 

Gene Name

 MCFD2 

Gene Synonyms/Alias

 SDNSF 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
143	IDYAEFAKSLQ****	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors. 

Sequence Annotation

 DOMAIN 68 103 EF-hand 1.
 DOMAIN 116 146 EF-hand 2.  

Keyword

 3D-structure; Alternative splicing; Calcium; Complete proteome; Disease mutation; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; Metal-binding; Protein transport; Reference proteome; Repeat; Signal; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 146 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
 GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0043687; P:post-translational protein modification; TAS:Reactome.
 GO:0018279; P:protein N-linked glycosylation via asparagine; TAS:Reactome.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom. 

Pfam

 PF13499; EF_hand_5 

SMART

  

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 

PRINTS