UniProt Accession

 IF2B_MOUSE; Q99L45; Q9CSH6; Q9CT12 

Genbank Protein ID

 AK011503; AK012817; BC003848 

Genbank Nucleotide ID

 BAB27663.1; BAB28490.2; AAH03848.1 

Protein Name

 Eukaryotic translation initiation factor 2 subunit 2 

Protein Synonyms/Alias

 Eukaryotic translation initiation factor 2 subunit beta; eIF-2-beta 

Gene Name

 Eif2s2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
203	EKRKFVMKPPQVVRV	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). 

Sequence Annotation

 ZN_FING 279 303 C4-type (Potential).
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 2 2 Phosphoserine (By similarity).
 MOD_RES 13 13 Phosphoserine (By similarity).
 MOD_RES 67 67 Phosphoserine.
 MOD_RES 105 105 Phosphoserine (By similarity).
 MOD_RES 158 158 Phosphoserine (By similarity).
 MOD_RES 216 216 Phosphoserine (By similarity).
 MOD_RES 263 263 N6-acetyllysine (By similarity).
 MOD_RES 291 291 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Initiation factor; Metal-binding; Phosphoprotein; Protein biosynthesis; Reference proteome; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 331 AA 

Protein Sequence

Gene Ontology

 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0003743; F:translation initiation factor activity; ISS:UniProtKB.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0002176; P:male germ cell proliferation; IMP:MGI.
 GO:0008584; P:male gonad development; IMP:MGI. 

Interpro

 IPR002735; Transl_init_fac_IF2/IF5.
 IPR016189; Transl_init_fac_IF2/IF5_N.
 IPR016190; Transl_init_fac_IF2/IF5_Zn-bd. 

Pfam

 PF01873; eIF-5_eIF-2B 

SMART

 SM00653; eIF2B_5 

PROSITE

  

PRINTS