| Tag | Content |
|---|
| CPLM ID | CPLM-004529 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Alpha-N-acetylgalactosaminidase |
Protein Synonyms/Alias | Alpha-galactosidase B |
Gene Name | NAGA |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 304 | LQNPLMIKINQDPLG | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids. |
Sequence Annotation | REGION 78 79 Substrate binding.
ACT_SITE 156 156 Nucleophile.
ACT_SITE 217 217 Proton donor.
BINDING 154 154 Substrate.
BINDING 188 188 Substrate.
BINDING 213 213 Substrate.
BINDING 217 217 Substrate.
MOD_RES 322 322 Phosphoserine.
MOD_RES 332 332 Phosphoserine.
CARBOHYD 124 124 N-linked (GlcNAc...).
CARBOHYD 177 177 N-linked (GlcNAc...).
CARBOHYD 201 201 N-linked (GlcNAc...).
CARBOHYD 359 359 N-linked (GlcNAc...) (Potential).
CARBOHYD 385 385 N-linked (GlcNAc...).
DISULFID 38 80
DISULFID 42 49
DISULFID 127 158
DISULFID 187 209 |
Keyword | 3D-structure; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Epilepsy; Glycoprotein; Glycosidase; Hydrolase; Lysosome; Phosphoprotein; Reference proteome; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 411 AA |
Protein Sequence | MLLKTVLLLG HVAQVLMLDN GLLQTPPMGW LAWERFRCNI NCDEDPKNCI SEQLFMEMAD 60
RMAQDGWRDM GYTYLNIDDC WIGGRDASGR LMPDPKRFPH GIPFLADYVH SLGLKLGIYA 120
DMGNFTCMGY PGTTLDKVVQ DAQTFAEWKV DMLKLDGCFS TPEERAQGYP KMAAALNATG 180
RPIAFSCSWP AYEGGLPPRV NYSLLADICN LWRNYDDIQD SWWSVLSILN WFVEHQDILQ 240
PVAGPGHWND PDMLLIGNFG LSLEQSRAQM ALWTVLAAPL LMSTDLRTIS AQNMDILQNP 300
LMIKINQDPL GIQGRRIHKE KSLIEVYMRP LSNKASALVF FSCRTDMPYR YHSSLGQLNF 360
TGSVIYEAQD VYSGDIISGL RDETNFTVII NPSGVVMWYL YPIKNLEMSQ Q 411 |
Gene Ontology | GO:0005737; C:cytoplasm; IBA:RefGenome. GO:0005764; C:lysosome; IEA:UniProtKB-SubCell. GO:0004557; F:alpha-galactosidase activity; IBA:RefGenome. GO:0008456; F:alpha-N-acetylgalactosaminidase activity; IDA:UniProtKB. GO:0016052; P:carbohydrate catabolic process; IDA:UniProtKB. GO:0016139; P:glycoside catabolic process; IBA:RefGenome. GO:0046477; P:glycosylceramide catabolic process; IBA:RefGenome. GO:0009311; P:oligosaccharide metabolic process; IBA:RefGenome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |