| Tag | Content |
|---|
| CPLM ID | CPLM-004832 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | U4/U6 small nuclear ribonucleoprotein PRP4 |
Protein Synonyms/Alias | Pre-mRNA-processing protein 4 |
Gene Name | PRP4 |
Gene Synonyms/Alias | RNA4; YPR178W; P9705.6 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 3 | *****MSKYIALENL | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Involved in RNA splicing. Is required for the association of U4/U6 snRNP with U5 snRNP in an early step of spliceosome assembly. |
Sequence Annotation | REPEAT 173 212 WD 1.
REPEAT 216 256 WD 2.
REPEAT 263 302 WD 3.
REPEAT 305 344 WD 4.
REPEAT 347 386 WD 5.
REPEAT 391 432 WD 6.
REPEAT 435 464 WD 7. |
Keyword | Complete proteome; mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat; Spliceosome; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 465 AA |
Protein Sequence | MSKYIALENL PVDLQHKGAT QNESTADILK QLPHERLQAV LEKIPEEDLE VRRLLSILKK 60
PEVVENEDVQ QRRIRLAEIL MVDEIDLENI NNMENINGEE VDEEDDEDFF TPATSELIFA 120
RRFLINYSLE RSRKRLQKEM ERHQKFNTRQ ELLSRRTELQ RMANLELAGS QLVSTKPISA 180
VSLSTDDMVV ATGSWAGDLQ VLNSQTLQPL TQKLDSHVGK IGAIDWHPDS NNQMISCAED 240
GLIKNFQYSN EEGGLRLLGD LVGHERRISD VKYHPSGKFI GSASHDMTWR LWDASTHQEL 300
LLQEGHDKGV FSLSFQCDGS LVCSGGMDSL SMLWDIRSGS KVMTLAGHSK PIYTVAWSPN 360
GYQVATGGGD GIINVWDIRK RDEGQLNQIL AHRNIVTQVR FSKEDGGKKL VSCGYDNLIN 420
VYSSDTWLKM GSLAGHTDKI ISLDISNNSH FLVSGGWDRS IKLWN 465 |
Gene Ontology | GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW. GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IDA:SGD. GO:0000398; P:mRNA splicing, via spliceosome; IPI:SGD. |
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SMART | |
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