UniProt Accession

 DPOE4_HUMAN; Q9NR33; Q53TR2 

Genbank Protein ID

 AF261688; AC007400; BC031331 

Genbank Nucleotide ID

 AAF90132.1; AAY15030.1; AAH31331.1 

Protein Name

 DNA polymerase epsilon subunit 4 

Protein Synonyms/Alias

 DNA polymerase II subunit 4; DNA polymerase epsilon subunit p12 

Gene Name

 POLE4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
51	ARVKALVKADPDVTL	ubiquitination	[1]

Reference

 [1] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 

Functional Description

 May play a role in allowing polymerase epsilon to carry out its replication and/or repair function. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 11 11 Phosphothreonine.
 MOD_RES 25 25 Phosphoserine.  

Keyword

 Acetylation; Complete proteome; DNA-binding; DNA-directed DNA polymerase; Nucleotidyltransferase; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 117 AA 

Protein Sequence

Gene Ontology

 GO:0005671; C:Ada2/Gcn5/Ada3 transcription activator complex; IDA:BHF-UCL.
 GO:0008622; C:epsilon DNA polymerase complex; IDA:UniProtKB.
 GO:0003887; F:DNA-directed DNA polymerase activity; TAS:ProtInc.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0043966; P:histone H3 acetylation; IDA:BHF-UCL. 

Interpro

 IPR003958; CBFA_NFYB_domain.
 IPR009072; Histone-fold. 

Pfam

 PF00808; CBFD_NFYB_HMF 

SMART

  

PROSITE

  

PRINTS