UniProt Accession

 E7ET49_HUMAN; E7ET49 

Genbank Protein ID

 AC009412; AC072052 

Genbank Nucleotide ID

  

Protein Name

 Sn1-specific diacylglycerol lipase beta 

Protein Synonyms/Alias

  

Gene Name

 DAGLB 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
165	LLCCCIGKDDHTRVA	ubiquitination	[1]
468	VTNLEDLKRRILRVV	ubiquitination	[2, 3]
587	SHEAEFSKILIGPKM	ubiquitination	[3, 4]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Hydrolase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 631 AA 

Protein Sequence

Gene Ontology

 GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
 GO:0006629; P:lipid metabolic process; IEA:InterPro. 

Interpro

 IPR002921; Lipase_3. 

Pfam

 PF01764; Lipase_3 

SMART

  

PROSITE

  

PRINTS