UniProt Accession

 PYRF_YEAST; P03962; D3DLM7 

Genbank Protein ID

 K02206; K02207; U18530; U89671; M12926; X00191; U89927; U63018; BK006939 

Genbank Nucleotide ID

 AAA34824.1; AAA34825.1; AAB64498.1; AAB49978.1; AAA35199.1; CAA25010.1; AAB64383.1; AAC53678.1; DAA07631.1 

Protein Name

 Orotidine 5'-phosphate decarboxylase 

Protein Synonyms/Alias

 OMP decarboxylase; OMPDCase; OMPdecase; Uridine 5'-monophosphate synthase; UMP synthase 

Gene Name

 URA3 

Gene Synonyms/Alias

 YEL021W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
20	HPSPVAAKLFNIMHE	ubiquitination	[1]
28	LFNIMHEKQTNLCAS	ubiquitination	[1]
42	SLDVRTTKELLELVE	ubiquitination	[1]
54	LVEALGPKICLLKTH	ubiquitination	[1]
59	GPKICLLKTHVDILT	ubiquitination	[1]
78	EGTVKPLKALSAKYN	ubiquitination	[1]
93	FLLFEDRKFADIGNT	ubiquitination	[1, 2, 3, 4, 5]
102	ADIGNTVKLQYSAGV	ubiquitination	[1]
142	QAAEEVTKEPRGLLM	ubiquitination	[1, 3]
176	VDIAKSDKDFVIGFI	ubiquitination	[3]
209	PGVGLDDKGDALGQQ	ubiquitination	[1, 2, 3, 4, 5]
240	VGRGLFAKGRDAKVE	ubiquitination	[1]
253	VEGERYRKAGWEAYL	ubiquitination	[1, 2, 4, 5]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] A proteomics approach to understanding protein ubiquitination.
 Peng J, Schwartz D, Elias JE, Thoreen CC, Cheng D, Marsischky G, Roelofs J, Finley D, Gygi SP.
 Nat Biotechnol. 2003 Aug;21(8):921-6. [PMID: 12872131]
 [3] Systematic approach for validating the ubiquitinated proteome.
 Seyfried NT, Xu P, Duong DM, Cheng D, Hanfelt J, Peng J.
 Anal Chem. 2008 Jun 1;80(11):4161-9. [PMID: 18433149]
 [4] Computational identification of ubiquitylation sites from protein sequences.
 Tung CW, Ho SY.
 BMC Bioinformatics. 2008 Jul 15;9:310. [PMID: 18625080]
 [5] Identification, analysis, and prediction of protein ubiquitination sites.
 Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM.
 Proteins. 2010 Feb 1;78(2):365-80. [PMID: 19722269] 

Functional Description

  

Sequence Annotation

 REGION 59 61 Substrate binding.
 REGION 91 100 Substrate binding.
 ACT_SITE 93 93 Proton donor.
 BINDING 37 37 Substrate.
 BINDING 217 217 Substrate.
 BINDING 235 235 Substrate.
 CROSSLNK 93 93 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 209 209 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 253 253 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Complete proteome; Decarboxylase; Isopeptide bond; Lyase; Pyrimidine biosynthesis; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 267 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:SGD.
 GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IDA:SGD.
 GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IMP:SGD.
 GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0006222; P:UMP biosynthetic process; IDA:SGD. 

Interpro

 IPR013785; Aldolase_TIM.
 IPR014732; OMPdecase.
 IPR018089; OMPdecase_AS.
 IPR001754; OMPdeCOase_dom.
 IPR011060; RibuloseP-bd_barrel. 

Pfam

 PF00215; OMPdecase 

SMART

 SM00934; OMPdecase 

PROSITE

 PS00156; OMPDECASE 

PRINTS