Tag | Content |
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CPLM ID | CPLM-014958 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | WAS/WASL-interacting protein family member 1 |
Protein Synonyms/Alias | Wiskott-Aldrich syndrome protein-interacting protein; WASP-interacting protein |
Gene Name | Wipf1 |
Gene Synonyms/Alias | Waspip; Wip |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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61 | RSAPILDKPKGAGGG | acetylation | [1] | 135 | GGRATSAKPFSSPSG | acetylation | [1] | 250 | PSRALDDKPPPPPPP | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. Plays a role in the formation of cell ruffles (By similarity). May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. |
Sequence Annotation | DOMAIN 32 49 WH2. REPEAT 336 345 XRSGPXPPXP motif 1. REPEAT 358 367 XRSGPXPPXP motif 2. REPEAT 394 403 XRSGPXPPXP motif 3. REGION 45 48 Binds actin (By similarity). MOD_RES 263 263 Phosphoserine (By similarity). MOD_RES 324 324 Phosphoserine (By similarity). MOD_RES 326 326 Phosphothreonine (By similarity). MOD_RES 329 329 Phosphothreonine (By similarity). MOD_RES 334 334 Phosphoserine (By similarity). |
Keyword | Actin-binding; Alternative splicing; Cell projection; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 487 AA |
Protein Sequence | MPVPPPPAPP PPPTFALANT EKPSLNKTEQ AGRNALLSDI SKGKKLKKTV TNDRSAPILD 60 KPKGAGGGYG GGSGGGGGGG SSGGGGNFGG GGPPGLGGLF QAGMPKLRST ANRDNDSGGS 120 RPPILPPGGR ATSAKPFSSP SGPGRFPAPS PGHRSGPPEP PRNRMPPPRP DVGSKPDSLP 180 PPVPNTPRPI PSSLHNRGSP AGLGAPRPPF PGNRGAAFGA GSVRQNLSSS SSPFPRPPLP 240 PTPSRALDDK PPPPPPPVGN RPSMHREAVP PPPSQNSKPP VPSTPRPGAG SQAPPPPPPS 300 RPGPPPLPPT SSDEIPRLPQ RNLSLTSPTP PLPSPGRSGP LPPPPTERPP PPVRDPPGRS 360 GPLPPPPPIN RNGSTARALP ATPQLPSRSG MDSPRSGPRP PLPPDRPGAG APPPPPPSTS 420 VRNGFQDSSC EDEWESRFYF HPISDLPPPE PYVPTTKTYP SKVARSESRS GSNRRERGAP 480 PLPPIPR 487 |
Gene Ontology | GO:0005884; C:actin filament; IDA:RGD. GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell. GO:0001726; C:ruffle; IEA:UniProtKB-SubCell. GO:0030036; P:actin cytoskeleton organization; IMP:RGD. GO:0030048; P:actin filament-based movement; IEA:Compara. GO:0046827; P:positive regulation of protein export from nucleus; IDA:RGD. |
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