CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006116
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Actin-related protein 3 
Protein Synonyms/Alias
 Actin-2; Actin-like protein 3; Actin-like protein 66B 
Gene Name
 Arp66B 
Gene Synonyms/Alias
 Actr66B; CG7558 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
244DIAKEFAKYDTEPGKacetylation[1]
251KYDTEPGKWIRNFSGacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). 
Sequence Annotation
  
Keyword
 Actin-binding; ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 418 AA 
Protein Sequence
MAGRLPACVI DVGTGYSKLG FAGNKEPQFI IPSAIAIKES ARVGDTNTRR ITKGIEDLDF 60
FIGDEAFDAT GYSIKYPVRH GLVEDWDLME RFLEQCVFKY LRAEPEDHYF LLTEPPLNTP 120
ENREYTAEIM FETFNVPGLY IAVQAVLALA ASWASRSAEE RTLTGIVVDS GDGVTHVIPV 180
AEGYVIGSCI KHIPIAGRNI TSFIQSLLRE REVGIPPEQS LETAKAIKEK HCYICPDIAK 240
EFAKYDTEPG KWIRNFSGVN TVTKAPFNVD VGYERFLGPE IFFHPEFSNP DFTIPLSEIV 300
DNVIQNCPID VRRPLYNNIV LSGGSTMFKD FGRRLQRDIK RSVDTRLRIS ENLSEGRIKP 360
KPIDVQVITH HMQRYAVWFG GSMLASTPEF YQVCHTKAAY EEYGPSICRH NPVFGTMT 418 
Gene Ontology
 GO:0005884; C:actin filament; ISS:FlyBase.
 GO:0005885; C:Arp2/3 protein complex; ISS:FlyBase.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0030027; C:lamellipodium; IDA:FlyBase.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005200; F:structural constituent of cytoskeleton; ISS:FlyBase.
 GO:0030037; P:actin filament reorganization involved in cell cycle; IPI:FlyBase.
 GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:InterPro.
 GO:0007413; P:axonal fasciculation; IMP:FlyBase.
 GO:0022416; P:chaeta development; IMP:FlyBase.
 GO:0006886; P:intracellular protein transport; IMP:FlyBase.
 GO:0007520; P:myoblast fusion; IMP:FlyBase.
 GO:0030713; P:ovarian follicle cell stalk formation; IMP:FlyBase.
 GO:0006911; P:phagocytosis, engulfment; IMP:FlyBase.
 GO:0051491; P:positive regulation of filopodium assembly; IMP:FlyBase.
 GO:0010592; P:positive regulation of lamellipodium assembly; IMP:FlyBase.
 GO:0045747; P:positive regulation of Notch signaling pathway; IMP:FlyBase.
 GO:0030589; P:pseudocleavage involved in syncytial blastoderm formation; IPI:FlyBase. 
Interpro
 IPR004000; Actin-related.
 IPR020902; Actin/actin-like_CS.
 IPR015623; Arp3. 
Pfam
 PF00022; Actin 
SMART
 SM00268; ACTIN 
PROSITE
 PS01132; ACTINS_ACT_LIKE 
PRINTS