UniProt Accession

 ST2A1_HUMAN; Q06520 

Genbank Protein ID

 L20000; X70222; U08024; U08025; X84816; L36196; L36191; L36192; L36193; L36194; L36195; U13061; U13056; U13057; U13058; U13059; U13060; S43859; BC020755 

Genbank Nucleotide ID

 AAA35758.1; CAA49755.1; AAA17749.1; AAA17750.1; CAA59274.1; AAA75491.1; AAA75491.1; AAA75491.1; AAA75491.1; AAA75491.1; AAA75491.1; AAC51353.1; AAC51353.1; AAC51353.1; AAC51353.1; AAC51353.1; AAC51353.1; AAB23169.2; AAH20755.1 

Protein Name

 Bile salt sulfotransferase 

Protein Synonyms/Alias

 Dehydroepiandrosterone sulfotransferase; DHEA-ST; Hydroxysteroid Sulfotransferase; HST; ST2; ST2A3; Sulfotransferase 2A1; ST2A1 

Gene Name

 SULT2A1 

Gene Synonyms/Alias

 HST; STD 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
177	WMPMREEKNFLLLSY	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. 

Sequence Annotation

 NP_BIND 44 49 PAPS.
 NP_BIND 218 223 PAPS.
 NP_BIND 247 249 PAPS.
 ACT_SITE 99 99 Proton acceptor.
 BINDING 72 72 Substrate.
 BINDING 77 77 Substrate.
 BINDING 121 121 PAPS.
 BINDING 129 129 PAPS.
 BINDING 184 184 PAPS.  

Keyword

 3D-structure; Bile acid catabolism; Complete proteome; Cytoplasm; Direct protein sequencing; Lipid degradation; Lipid metabolism; Polymorphism; Reference proteome; Steroid metabolism; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 285 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0047704; F:bile-salt sulfotransferase activity; IEA:EC.
 GO:0008146; F:sulfotransferase activity; IDA:BHF-UCL.
 GO:0050427; P:3'-phosphoadenosine 5'-phosphosulfate metabolic process; TAS:Reactome.
 GO:0030573; P:bile acid catabolic process; IEA:UniProtKB-KW.
 GO:0044255; P:cellular lipid metabolic process; TAS:Reactome.
 GO:0007586; P:digestion; NAS:ProtInc.
 GO:0008202; P:steroid metabolic process; TAS:ProtInc.
 GO:0051923; P:sulfation; IDA:BHF-UCL.
 GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR000863; Sulfotransferase_dom. 

Pfam

 PF00685; Sulfotransfer_1 

SMART

  

PROSITE

  

PRINTS