UniProt Accession

 GP174_HUMAN; Q9BXC1; Q2M3F7 

Genbank Protein ID

 AF345567; AB083599; AY242133; AL590222; BC104922; BC104924 

Genbank Nucleotide ID

 AAK29070.1; BAB89312.1; AAO92300.1; CAD13458.1; AAI04923.1; AAI04925.1 

Protein Name

 Probable G-protein coupled receptor 174 

Protein Synonyms/Alias

  

Gene Name

 GPR174 

Gene Synonyms/Alias

 FKSG79 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
167	DTSGNRTKCFVDLPT	ubiquitination	[1, 2]
262	LVKSNEIKSCLARRV	ubiquitination	[1, 2]
317	DSIQLHAKSFVSNHT	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Putative receptor for purines coupled to G-proteins (By similarity). 

Sequence Annotation

 CARBOHYD 4 4 N-linked (GlcNAc...) (Potential).
 CARBOHYD 164 164 N-linked (GlcNAc...) (Potential).
 DISULFID 91 168 By similarity.  

Keyword

 Cell membrane; Complete proteome; Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 333 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0045028; F:G-protein coupled purinergic nucleotide receptor activity; IEA:InterPro. 

Interpro

 IPR000276; GPCR_Rhodpsn.
 IPR017452; GPCR_Rhodpsn_7TM.
 IPR002286; purinergic_P2Y_rcpt. 

Pfam

 PF00001; 7tm_1 

SMART

  

PROSITE

 PS00237; G_PROTEIN_RECEP_F1_1
 PS50262; G_PROTEIN_RECEP_F1_2 

PRINTS

 PR00237; GPCRRHODOPSN.
 PR01157; P2YPURNOCPTR.