UniProt Accession

 PHB1_YEAST; P40961; D6VUR4 

Genbank Protein ID

 U16737; Z72917; AY558096; BK006941 

Genbank Nucleotide ID

 AAA53144.1; CAA97145.1; AAS56422.1; DAA08225.1 

Protein Name

 Prohibitin-1 

Protein Synonyms/Alias

  

Gene Name

 PHB1 

Gene Synonyms/Alias

 PHB; YGR132C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
6	**MSNSAKLIDVITK	acetylation	[1]
188	FTKAVEQKQIAQQDA	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Has an antiproliferative activity. Regulates replicative life span. 

Sequence Annotation

  

Keyword

 Coiled coil; Complete proteome; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 287 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IDA:SGD.
 GO:0007007; P:inner mitochondrial membrane organization; IMP:SGD.
 GO:0000001; P:mitochondrion inheritance; IMP:SGD.
 GO:0070584; P:mitochondrion morphogenesis; IMP:SGD.
 GO:0045861; P:negative regulation of proteolysis; IPI:SGD.
 GO:0006457; P:protein folding; IPI:SGD.
 GO:0001302; P:replicative cell aging; IMP:SGD. 

Interpro

 IPR001107; Band_7.
 IPR000163; Prohibitin. 

Pfam

 PF01145; Band_7 

SMART

 SM00244; PHB 

PROSITE

  

PRINTS

 PR00679; PROHIBITIN.