CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024692
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 TOX high mobility group box family member 3 
Protein Synonyms/Alias
 Trinucleotide repeat-containing gene 9 protein 
Gene Name
 Tox3 
Gene Synonyms/Alias
 Tnrc9 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
256KDPNEPQKPVSAYALacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region. 
Sequence Annotation
 DNA_BIND 254 322 HMG box.  
Keyword
 Activator; Apoptosis; Complete proteome; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 577 AA 
Protein Sequence
MDVRFYPAAA GDPAGLDFAQ CLGYYGYSKL GNNNYMNMAE ANNAFFAASE QTFHTPSLGD 60
EEFEIPPITP PPESDPTLGM PDVLLPFQTL SDPLPSQGNE FTPQFPPQSL DLPSITISRN 120
LVEQDGVLHS NGLHMDQSHT QVSQYRQDPS LVMRSIVHMT DAARSGIMPP AQLTTINQSQ 180
LSAQLGLNLG GASVPHTSPS PPASKSATPS PSSSINEEDA DETNRAVGEK RTAPDSGKKP 240
KTPKKKKKKD PNEPQKPVSA YALFFRDTQA AIKGQNPNAT FGEVSKIVAS MWDSLGEEQK 300
QVYKRKTEAA KKEYLKALAA YRASLVSKAA AESAEAQTIR SVQQTLASTN LTSSLLLNTS 360
LSQHGTVPAS PQTLPQSLPR SIAPKPLTMR LPMSQIVTSV TIAANMPSNI GAPLISSMGT 420
TMVGSVSSTQ VSPSVQTQQH QLQLQQQQQQ QQQQMQQMQH QQLQQHQMHQ QIQQQMQQQH 480
FQHHMQQHLQ QQQQQHLQQQ ISQQQLQQQL QQHLQLQQQL QHMQHQSQPS PRQHSPVTSQ 540
ITSPIPAIGS PQPASQQHQP QIQSQTQTQV LPQVSIF 577 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003682; F:chromatin binding; ISS:UniProtKB.
 GO:0034056; F:estrogen response element binding; ISS:UniProtKB.
 GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0019722; P:calcium-mediated signaling; IDA:UniProtKB.
 GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR009071; HMG_box_dom. 
Pfam
 PF00505; HMG_box 
SMART
 SM00398; HMG 
PROSITE
 PS00353; HMG_BOX_1
 PS50118; HMG_BOX_2 
PRINTS