UniProt Accession

 ZSWM7_HUMAN; Q19AV6 

Genbank Protein ID

 DQ530600 

Genbank Nucleotide ID

 ABF72190.1 

Protein Name

 Zinc finger SWIM domain-containing protein 7 

Protein Synonyms/Alias

 SWIM domain-containing and Srs2-interacting protein 1 homolog; SWIM-type zinc finger domain-containing protein 7 

Gene Name

 ZSWIM7 

Gene Synonyms/Alias

 SWS1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
136	TDILLMEKKQEA***	ubiquitination	[1]
137	DILLMEKKQEA****	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. 

Sequence Annotation

 ZN_FING 66 114 SWIM-type.  

Keyword

 Complete proteome; DNA damage; DNA recombination; DNA repair; Metal-binding; Nucleus; Reference proteome; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 140 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0097196; C:Shu complex; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0000724; P:double-strand break repair via homologous recombination; IMP:UniProtKB.
 GO:0050821; P:protein stabilization; IMP:UniProtKB. 

Interpro

 IPR007527; Znf_SWIM. 

Pfam

 PF04434; SWIM 

SMART

  

PROSITE

 PS50966; ZF_SWIM 

PRINTS