| Tag | Content |
|---|
| CPLM ID | CPLM-023973 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ancient ubiquitous protein 1 |
Protein Synonyms/Alias | |
Gene Name | AUP1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 143 | GELVESLKRFCASTR | ubiquitination | [1] | | 250 | RVQQLVAKELGQTGT | ubiquitination | [1] | | 359 | LPTASASKFPSSGPV | ubiquitination | [1] | | 377 | PTALTFAKSSWARQE | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. |
Sequence Annotation | DOMAIN 362 404 CUE.
MOD_RES 354 354 Phosphoserine.
MOD_RES 358 358 Phosphoserine.
MOD_RES 429 429 Phosphoserine.
MOD_RES 433 433 Phosphothreonine. |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Endoplasmic reticulum; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 476 AA |
Protein Sequence | MELPSGPGPE RLFDSHRLPG DCFLLLVLLL YAPVGFCLLV LRLFLGIHVF LVSCALPDSV 60
LRRFVVRTMC AVLGLVARQE DSGLRDHSVR VLISNHVTPF DHNIVNLLTT CSTPLLNSPP 120
SFVCWSRGFM EMNGRGELVE SLKRFCASTR LPPTPLLLFP EEEATNGREG LLRFSSWPFS 180
IQDVVQPLTL QVQRPLVSVT VSDASWVSEL LWSLFVPFTV YQVRWLRPVH RQLGEANEEF 240
ALRVQQLVAK ELGQTGTRLT PADKAEHMKR QRHPRLRPQS AQSSFPPSPG PSPDVQLATL 300
AQRVKEVLPH VPLGVIQRDL AKTGCVDLTI TNLLEGAVAF MPEDITKGTQ SLPTASASKF 360
PSSGPVTPQP TALTFAKSSW ARQESLQERK QALYEYARRR FTERRAQEAD 410 |
Gene Ontology | GO:0005783; C:endoplasmic reticulum; IDA:HPA. GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005634; C:nucleus; IDA:HPA. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |