CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010058
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 Threonine--tRNA ligase 
Protein Synonyms/Alias
 Threonyl-tRNA synthetase; ThrRS 
Gene Name
 thrS 
Gene Synonyms/Alias
 MPN_553; MP289 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
492AAKKLYQKLLKENIRacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
  
Sequence Annotation
 REGION 167 464 Catalytic.
 METAL 260 260 Zinc; catalytic (By similarity).
 METAL 311 311 Zinc; catalytic (By similarity).
 METAL 441 441 Zinc; catalytic (By similarity).  
Keyword
 Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Cytoplasm; Ligase; Metal-binding; Nucleotide-binding; Protein biosynthesis; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 564 AA 
Protein Sequence
MLAGVLLLQS WLKANYPQVQ FGSYGVQEGE FYLDFKVEKS FSIKEFEQLE QDLNAYFNQL 60
NNVVQTKIDK TKSLKFFQAD PFTTTLIESI ESNSLVVTTV NEQTFWVHDL VLPLPKQGFV 120
KLLNVSANYF LGDPTKPQLQ RLVGIFAASK EQLKSLIAAN EQKYQNDHRA IGKRLEIFTF 180
DPLVGAGFPI WLEKGAVLKK IIGDFVHYQQ LMFGFKTVSS PVLANLELYK ISGHYVHYSE 240
DMFPSVKLEN QMMMLRPMTC PHHCLIFKHK RRSYKELPQR FCEDSILHRF EASGGLTGLE 300
RVRCMTLLDN HIFCRTDQIK AEIKNAFKLI QTVNNKFGFS FDRIDLALHD PNNKAKFIDN 360
DQLWANSESQ IESVFKELNV PYKIDVGAAA FYGPKIDFQF KTALNKMITI ATIQLDFLLP 420
ERFELRYFDE QSNAQTPVII HVGIVGTYER FIAALLEKTH GNLPLWMAPV QVVVIPVNID 480
KHEKAAKKLY QKLLKENIRV SLDESEDRLG KKVRTAIVNK IPLQIIVGDK EMQDLTRITC 540
RGFKGEKVQK LYWANFVKKV RKDG 564 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004829; F:threonine-tRNA ligase activity; IEA:HAMAP.
 GO:0006435; P:threonyl-tRNA aminoacylation; IEA:HAMAP. 
Interpro
 IPR002314; aa-tRNA-synt_IIb_cons-dom.
 IPR006195; aa-tRNA-synth_II.
 IPR004154; Anticodon-bd.
 IPR002320; Thr-tRNA-ligase_IIa.
 IPR018163; Thr/Ala-tRNA-synth_IIc_edit. 
Pfam
 PF03129; HGTP_anticodon
 PF00587; tRNA-synt_2b 
SMART
  
PROSITE
 PS50862; AA_TRNA_LIGASE_II 
PRINTS
 PR01047; TRNASYNTHTHR.