UniProt Accession

 MTNA_HUMAN; Q9BV20; Q8NDC9 

Genbank Protein ID

 AY358176; AL834276; CH471106; CH471106; BC001703 

Genbank Nucleotide ID

 AAQ88543.1; CAD38951.1; EAW84370.1; EAW84371.1; AAH01703.1 

Protein Name

 Methylthioribose-1-phosphate isomerase 

Protein Synonyms/Alias

 M1Pi; MTR-1-P isomerase; Mediator of RhoA-dependent invasion; S-methyl-5-thioribose-1-phosphate isomerase; Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein 

Gene Name

 MRI1 

Gene Synonyms/Alias

 MRDI; UNQ6390/PRO21135 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
23	LDQLLLPKQSRYEAV	ubiquitination	[1]
259	ANGDTANKVGTYQLA	ubiquitination	[1, 2]
293	DLRLETGKEIIIEER	ubiquitination	[1, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover. 

Sequence Annotation

 ACT_SITE 248 248 Proton donor.  

Keyword

 Alternative splicing; Amino-acid biosynthesis; Cell projection; Complete proteome; Cytoplasm; Isomerase; Methionine biosynthesis; Nucleus; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 369 AA 

Protein Sequence

Gene Ontology

 GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0046523; F:S-methyl-5-thioribose-1-phosphate isomerase activity; IBA:RefGenome.
 GO:0019284; P:L-methionine biosynthetic process from S-adenosylmethionine; IEA:HAMAP.
 GO:0019509; P:L-methionine salvage from methylthioadenosine; IBA:RefGenome.
 GO:0006595; P:polyamine metabolic process; TAS:Reactome. 

Interpro

 IPR000649; IF-2B-related.
 IPR005251; IF-2BI_MTNA.
 IPR011559; Initiation_fac_2B_a/b/d.
 IPR027363; M1Pi_N. 

Pfam

 PF01008; IF-2B 

SMART

  

PROSITE

  

PRINTS