CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024314
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 G patch domain-containing protein 8 
Protein Synonyms/Alias
  
Gene Name
 Gpatch8 
Gene Synonyms/Alias
 Gpatc8; Kiaa0553 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
307VSFSFAKKAPVKLESacetylation[1]
311FAKKAPVKLESIASVacetylation[1]
479GPSEPGGKTETKKGSacetylation[2]
1100TARLLLEKIQSRKVEacetylation[2]
1146LPPSLGNKPVLPMIGacetylation[1, 2]
1341IQQQLLAKQVKAFPAubiquitination[3]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
 DOMAIN 40 86 G-patch.
 ZN_FING 136 160 C2H2-type.
 MOD_RES 648 648 Phosphoserine (By similarity).
 MOD_RES 733 733 Phosphoserine (By similarity).
 MOD_RES 735 735 Phosphoserine (By similarity).
 MOD_RES 753 753 Phosphoserine (By similarity).
 MOD_RES 985 985 Phosphoserine (By similarity).
 MOD_RES 1018 1018 Phosphoserine (By similarity).
 MOD_RES 1037 1037 Phosphoserine (By similarity).
 MOD_RES 1039 1039 Phosphoserine (By similarity).
 MOD_RES 1085 1085 Phosphoserine (By similarity).  
Keyword
 Coiled coil; Complete proteome; Metal-binding; Phosphoprotein; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1505 AA 
Protein Sequence
MADRFSRFNE DRDFQGNHFD QYEEGHLEIE QASLDKPIES DNIGHRLLQK HGWKLGQGLG 60
KSLQGRTDPI PIVVKYDVMG MGRMEMELDY AEDATERRRV LEVEKEDTEE LRQKYKDYVD 120
KEKAIAKALE DLRANFYCEL CDKQYQKHQE FDNHINSYDH AHKQRLKDLK QREFARNVSS 180
RSRKDEKKQE KALRRLHELA EQRKQAECAP GSGPMFRPTT VAVDEDGGEE DKDESSTNSG 240
ASAVSSCGFG ADFSTDKGGS FTSVQITNTT GLSQAPGLAS QGISFGIKNN LGPPLQKLGV 300
SFSFAKKAPV KLESIASVFK DHAEEGSSED GTKADEKSSD QGVQKVGDTD GTGNLDGKKE 360
DEDPQDGGSL ASTLSKLKRM KREEGTGATE PEYYHYIPPA HCKVKPNFPF LLFMRASEQM 420
EGDHSAHSKS APENRKSSSP KPQGCSKTAA SPGAERTVSE ASELQKEAAV AGPSEPGGKT 480
ETKKGSGGGE DEQSVESRET SESPMCESNP KDISQATPAT KAGQGPKHPT GPFFPVLSKD 540
ESTALQWPSE LLIFTKAEPS ISYSCNPLYF DFKLSRNKDA KAKGTEKPKD VAGSSKDHLQ 600
SLDPREPNKS QEEEQDVVLS SEGRVDEPAS GAACSSLNKQ EPGGSHMSET EDTGRSHPSK 660
KEPSGKSHRH KKKKKHKKSS KHKRKHKADT EEKSSKAESG EKSKKRKKRK RKKNKSSAAA 720
DSERGPKSEP PGSGSPAPPR RRRRAQDDSQ RRSLPAEEGN SGKKDDGGGG SSCQDHSGRK 780
HKGEPPTSSC QRRANTKHSS RSSHRSQPSS GDEDSDDASS HRLHQKSPSQ YSEEEEEEEE 840
EEEEEDEDSG SEHSRSRSRS GHRHSSHRSS RRSYSSSSDA SSDQSCYSRQ HSYSDDSYSD 900
YSDRSRRHSK RSHDSDDSDY TSSKHRSKRH KYSSSDDDYS LSCSQSRSRS RSHTRERSRS 960
RGRSRSSSCS RSRSKRRSRS TTAHSWQRSR SYSRDRSRST RSPSQRSGSR KGSWGHESPE 1020
ERRSGRRDFI RSKIYRSQSP HYFQSGRGEG PGKKEDGRGD DSKGAGLPSQ NSNTGTGRGS 1080
ESDCSPEDKN SVTARLLLEK IQSRKVERKP NVCEEVLATP NKAGLKYKNP PQGYFGPKLP 1140
PSLGNKPVLP MIGKLPATRK SNKKCEESGL ERGEEQEHSE PEEGSPRSSD APFGHQFSEE 1200
AAGPLSDPPP EEPKSEEATA DHSVAPLGTP AHTDCYPGDP AISHNYLPDP SDGDTLESLD 1260
SGSQPGPVES SLLPIAPDLE HFPNYAPPSG EPSIESTDGT EDASLAPLES QPITFTPEEM 1320
EKYSKLQQAA QQHIQQQLLA KQVKAFPAST ALAPATPALQ PIHIQQPATA SATSITTVQH 1380
AILQHHAAAA AAAIGIHPHP HPQPLAQVHH IPQPHLTPIS LSHLTHSIIP GHPATFLASH 1440
PIHIIPASAI HPGPFTFHPV PHAALYPTLL APRPAAAAAT ALHLHPLLHP IFSGQDLQHP 1500
PSHGT 1505 
Gene Ontology
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR000467; G_patch_dom.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR022755; Znf_C2H2_jaz. 
Pfam
 PF01585; G-patch
 PF12171; zf-C2H2_jaz 
SMART
 SM00443; G_patch
 SM00355; ZnF_C2H2 
PROSITE
 PS50174; G_PATCH
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS