UniProt Accession

 FLOT2_HUMAN; Q14254 

Genbank Protein ID

 AC024267; M60922; BC017292; BT019478 

Genbank Nucleotide ID

 AAA65729.1; AAH17292.2; AAV38285.1 

Protein Name

 Flotillin-2 

Protein Synonyms/Alias

 Epidermal surface antigen; ESA; Membrane component chromosome 17 surface marker 1 

Gene Name

 FLOT2 

Gene Synonyms/Alias

 ESA1; M17S1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
81	QVKIMTEKELLAVAC	ubiquitination	[1]
100	GKNVQDIKNVVLQTL	ubiquitination	[2, 3]
132	QDRDQFAKLVREVAA	ubiquitination	[2]
155	EILSFTIKDVYDKVD	ubiquitination	[1]
160	TIKDVYDKVDYLSSL	ubiquitination	[1]
169	DYLSSLGKTQTAVVQ	ubiquitination	[1, 2]
370	ALPQIAAKIAAPLTK	ubiquitination	[1, 2, 3]
390	VLSGDNSKVTSEVNR	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function. 

Sequence Annotation

 LIPID 4 4 S-palmitoyl cysteine; by ZDHHC5.
 LIPID 19 19 S-palmitoyl cysteine.
 LIPID 20 20 S-palmitoyl cysteine; by ZDHHC5.  

Keyword

 Cell adhesion; Cell membrane; Complete proteome; Endosome; Lipoprotein; Membrane; Palmitate; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 428 AA 

Protein Sequence

Gene Ontology

 GO:0002080; C:acrosomal membrane; IEA:Compara.
 GO:0009986; C:cell surface; IDA:UniProtKB.
 GO:0030139; C:endocytic vesicle; IDA:UniProtKB.
 GO:0005768; C:endosome; IDA:UniProtKB.
 GO:0016600; C:flotillin complex; IEA:Compara.
 GO:0005886; C:plasma membrane; NAS:ProtInc.
 GO:0007155; P:cell adhesion; NAS:ProtInc.
 GO:0008544; P:epidermis development; TAS:ProtInc. 

Interpro

 IPR001107; Band_7. 

Pfam

 PF01145; Band_7 

SMART

 SM00244; PHB 

PROSITE

  

PRINTS