CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031722
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Chromodomain-helicase-DNA-binding protein 1-like 
Protein Synonyms/Alias
  
Gene Name
 CHD1L 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
10ALQKKYYKAILMKDLubiquitination[1]
15YYKAILMKDLDAFENubiquitination[1]
27FENETAKKVKLQNILubiquitination[1]
309EPSKEDRKSFEQLVNubiquitination[1]
319EQLVNLQKTLLEKASubiquitination[1]
324LQKTLLEKASQEGRSubiquitination[1, 2, 3]
349GLVEGSTKRKRVLSPubiquitination[1]
512DDKESRNKGQDLLALubiquitination[1, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 616 AA 
Protein Sequence
MSALQKKYYK AILMKDLDAF ENETAKKVKL QNILSQLRKC VDHPYLFDGV EPEPFEVGDH 60
LTEASGKLHL LDKLLAFLYS GGHRVLLFSQ MTQMLDILQD YMDYRGYSYE RVDGSVRGEE 120
RHLAIKNFGQ QPIFVFLLST RAGGVGMNLT AADTVIFVDS DFNPQNDLQA AARAHRIGQN 180
KSVKVIRLIG RDTVEEIVYR KAASKLQLTN MIIEGGHFTL GAQKPAADAD LQLSEILKFG 240
LDKLLASEGS TMDEIDLESI LGETKDGQWV SDALPAAEGG SRDQEEGKNH MYLFEGKDYS 300
KEPSKEDRKS FEQLVNLQKT LLEKASQEGR SLRNKGSVLI PGLVEGSTKR KRVLSPEELE 360
DRQKKRQEAA AKRRRLIEEK KRQKEEAEHK KKMAWWESNN YQSFCLPSEE SEPEDLENGE 420
ESSAELDYQD PDATSLKYVS GDVTHPQAGA EDALIVHCVD DSGHWGRGGL FTALEKRSAE 480
PRKIYELAGK MKDLSLGGVL LFPVDDKESR NKGQDLLALI VAQHRDRSNV LSGIKMAALE 540
EGLKKIFLAA KKKKASVHLP RIGHATKGFN WYGTERLIRK HLAARGIPTY IYYFPRSKSA 600
VLHAQSSSSS SRQLVP 616 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004386; F:helicase activity; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro. 
Interpro
 IPR002589; A1pp.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00271; Helicase_C 
SMART
 SM00490; HELICc 
PROSITE
 PS51194; HELICASE_CTER
 PS51154; MACRO 
PRINTS