| Tag | Content |
|---|
| CPLM ID | CPLM-021800 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sphingomyelin phosphodiesterase 3 |
Protein Synonyms/Alias | Neutral sphingomyelinase 2; nSMase-2; nSMase2; Neutral sphingomyelinase II |
Gene Name | Smpd3 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 116 | AALLSEWKGTGAGKS | ubiquitination | [1] | | 324 | ANSKLLYKTSVVKKA | ubiquitination | [1] | | 586 | YLAFPTSKSPGAGQK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Acts as a regulator of postnatal development and participates in bone and dentin mineralization. Overexpression enhances cell death, suggesting that it may be involved in apoptosis control. |
Sequence Annotation | ACT_SITE 639 639 Proton acceptor (By similarity).
METAL 362 362 Magnesium (By similarity).
LIPID 53 53 S-palmitoyl cysteine.
LIPID 54 54 S-palmitoyl cysteine.
LIPID 59 59 S-palmitoyl cysteine.
LIPID 395 395 S-palmitoyl cysteine.
LIPID 396 396 S-palmitoyl cysteine. |
Keyword | Cell cycle; Cell membrane; Complete proteome; Developmental protein; Golgi apparatus; Hydrolase; Lipid metabolism; Lipoprotein; Magnesium; Membrane; Metal-binding; Palmitate; Reference proteome; Sphingolipid metabolism. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 655 AA |
Protein Sequence | MVLYTTPFPN SCLSALHAVS WALIFPCYWL VDRLLASFIP TTYEKRQRAD DPCCLQLFCT 60
VLFTPVYLAL LVAALPFAFL GFIFWSPLQS ARRPYSYSRL EDKNPAGGAA LLSEWKGTGA 120
GKSFCFATAN VCLLPDSLAR LNNVFNTQAR AKEIGQRIRN GAARPQIKIY IDSPTNTSIS 180
AASFSSLVSP QGGDGSRAVP GSIKRTASVE YKGDGGRHPS DEAANGPASG EQADGSLEDS 240
CIVRIGGEEG GRPQEADDPA AGSQARNGAG GTPKGQTPNH NQRDGDSGSL GSPSASRESL 300
VKARAGQDSG GSGEPGANSK LLYKTSVVKK AAARRRRHPD EAFDHEVSAF FPANLDFLCL 360
QEVFDKRAAA KLKEQLHGYF EYILYDVGVY GCHGCCNFKC LNSGLFFASR YPVMDVAYHC 420
YPNGCSFDAL ASKGALFLKV QVGSTPQDQR IVGYIACTHL HAPPEDSAVR CEQLDLLQDW 480
LADFRKSTSS TSTANPEELV VFDVICGDLN FDNCSSDDKL EQQHSLFTRY KDPCRLGPGE 540
EKPWAIGTLL DTNGLYDEDV CTPDNLQKVL ESEEGRREYL AFPTSKSPGA GQKGRKDLLK 600
GNGRRIDYML HAEEGLCPDW KAEVEEFSFI TQLSGLTDHL PVAMRLMVSA GEEEA 655 |
Gene Ontology | GO:0000137; C:Golgi cis cisterna; IDA:MGI. GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004767; F:sphingomyelin phosphodiesterase activity; IDA:MGI. GO:0007049; P:cell cycle; IEA:UniProtKB-KW. GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. GO:0030072; P:peptide hormone secretion; IMP:MGI. GO:0007165; P:signal transduction; TAS:MGI. GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-UniPathway. GO:0006684; P:sphingomyelin metabolic process; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |