CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019299
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Unconventional myosin-XIX 
Protein Synonyms/Alias
 Myosin head domain-containing protein 1 
Gene Name
 MYO19 
Gene Synonyms/Alias
 MYOHD1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
101HAAPQPQKLKPHVFTubiquitination[1]
103APQPQKLKPHVFTVGubiquitination[1]
118EQTYRNVKSLIEPVNubiquitination[1, 2]
138SGESGAGKTWTSRCLubiquitination[1, 2]
163PASWESHKIAERIEQubiquitination[1, 2]
198NNSSRFGKFIQLQLNubiquitination[1]
222VQTYLLEKTRVACQAubiquitination[1, 2]
243HIFYQICKGASEDERubiquitination[1]
328CQPMDDAKYSVRTAAubiquitination[1, 3]
520SPCLGHNKLSREPSFubiquitination[1]
548AGLVEKNKDPIPPELubiquitination[1]
576GLFPTNPKEKTQEEPubiquitination[1, 2]
578FPTNPKEKTQEEPPGubiquitination[1]
597PVLTVVSKFKASLEQubiquitination[1, 2, 3]
742PMHCGRTKVFMTDSMubiquitination[1, 3]
830RMACLAAKELDGVEEubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
 Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. MYO19 is involved in mitochondrial motility. 
Sequence Annotation
 DOMAIN 50 684 Myosin head-like.
 DOMAIN 759 779 IQ 1.
 DOMAIN 783 812 IQ 2.
 REGION 829 970 Mitochondrial targeting.  
Keyword
 Actin-binding; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Mitochondrion; Mitochondrion outer membrane; Motor protein; Myosin; Nucleotide-binding; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 970 AA 
Protein Sequence
MLQQVNGHNP GSDGQAREYL REDLQEFLGG EVLLYKLDDL TRVNPVTLET VLRCLQARYM 60
ADTFYTNAGC TLVALNPFKP VPQLYSPELM REYHAAPQPQ KLKPHVFTVG EQTYRNVKSL 120
IEPVNQSIVV SGESGAGKTW TSRCLMKFYA VVATSPASWE SHKIAERIEQ RILNSNPVME 180
AFGNACTLRN NNSSRFGKFI QLQLNRAQQM TGAAVQTYLL EKTRVACQAS SERNFHIFYQ 240
ICKGASEDER LQWHLPEGAA FSWLPNPERS LEEDCFEVTR EAMLHLGIDT PTQNNIFKVL 300
AGLLHLGNIQ FAASEDEAQP CQPMDDAKYS VRTAASLLGL PEDVLLEMVQ IRTIRAGRQQ 360
QVFRKPCARA ECDTRRDCLA KLIYARLFDW LVSVINSSIC ADTDSWTTFI GLLDVYGFES 420
FPDNSLEQLC INYANEKLQQ HFVAHYLRAQ QEEYAVEGLE WSFINYQDNQ PCLDLIEGSP 480
ISICSLINEE CRLNRPSSAA QLQTRIETAL AGSPCLGHNK LSREPSFIVV HYAGPVRYHT 540
AGLVEKNKDP IPPELTRLLQ QSQDPLLMGL FPTNPKEKTQ EEPPGQSRAP VLTVVSKFKA 600
SLEQLLQVLH STTPHYIRCI KPNSQGQAQT FLQEEVLSQL EACGLVETIH ISAAGFPIRV 660
SHRNFVERYK LLRRLHPCTS SGPDSPYPAK GLPEWCPHSE EATLEPLIQD ILHTLPVLTQ 720
AAAITGDSAE AMPAPMHCGR TKVFMTDSML ELLECGRARV LEQCARCIQG GWRRHRHREQ 780
ERQWRAVMLI QAAIRSWLTR KHIQRLHAAA TVIKRAWQKW RIRMACLAAK ELDGVEEKHF 840
SQAPCSLSTS PLQTRLLEAI IRLWPLGLVL ANTAMGVGSF QRKLVVWACL QLPRGSPSSY 900
TVQTAQDQAG VTSIRALPQG SIKFHCRKSP LRYADICPEP SPYSITGFNQ ILLERHRLIH 960
VTSSAFTGLG 970 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
 GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003774; F:motor activity; IEA:InterPro. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR001609; Myosin_head_motor_dom.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00063; Myosin_head 
SMART
 SM00015; IQ
 SM00242; MYSc 
PROSITE
 PS50096; IQ 
PRINTS
 PR00193; MYOSINHEAVY.