CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015330
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger CCCH domain-containing protein 14 
Protein Synonyms/Alias
 Mammalian suppressor of tau pathology-2; MSUT-2; Renal carcinoma antigen NY-REN-37 
Gene Name
 ZC3H14 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
211QNSIHAAKQLDMQSSubiquitination[1]
334EAQESVTKTTNYSTVubiquitination[1]
344NYSTVPQKQTLPVAPubiquitination[1]
428SELSVAQKPEKLLERubiquitination[2]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Binds the polyadenosine RNA oligonucleotides. 
Sequence Annotation
 ZN_FING 595 620 C3H1-type 1.
 ZN_FING 621 640 C3H1-type 2.
 ZN_FING 641 656 C3H1-type 3.
 ZN_FING 682 699 C3H1-type 4.
 ZN_FING 701 719 C3H1-type 5.
 MOD_RES 357 357 N6-acetyllysine.
 MOD_RES 515 515 Phosphoserine.
 MOD_RES 620 620 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 736 AA 
Protein Sequence
MVMVANKKSQ DQMTEDLSLF LGNNTIRFTV WLHGVLDKLR SVTTEPSSLK SSDTNIFDSN 60
VPSNKSNFSR GDERRHEAAV PPLAIPSARP EKRDSRVSTS SQESKTTNVR QTYDDGAATR 120
LMSTVKPLRE PAPSEDVIDI KPEPDDLIDE DLNFVQENPL SQKKPTVTLT YGSSRPSIEI 180
YRPPASRNAD SGVHLNRLQF QQQQNSIHAA KQLDMQSSWV YETGRLCEPE VLNSLEETYS 240
PFFRNNSEKM SMEDENFRKR KLPVVSSVVK VKKFNHDGEE EEEDDDYGSR TGSISSSVSV 300
PAKPERRPSL PPSKQANKNL ILKAISEAQE SVTKTTNYST VPQKQTLPVA PRTRTSQEEL 360
LAEVVQGQSR TPRISPPIKE EETKGDSVEK NQGTQQRQLL SRLQIDPVMA ETLQMSQAEM 420
SELSVAQKPE KLLERCKYWP ACKNGDECAY HHPISPCKAF PNCKFAEKCL FVHPNCKYDA 480
KCTKPDCPFT HVSRRIPVLS PKPAVAPPAP PSSSQLCRYF PACKKMECPF YHPKHCRFNT 540
QCTRPDCTFY HPTINVPPRH ALKWIRPQTS E 571 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR000571; Znf_CCCH. 
Pfam
  
SMART
 SM00356; ZnF_C3H1 
PROSITE
 PS50103; ZF_C3H1 
PRINTS