UniProt Accession

 TPOR_HUMAN; P40238; Q5JUZ0 

Genbank Protein ID

 M90102; M90103; U68162; U68159; U68160; U68161; U68162; U68159; U68160; U68161; AL139289; CH471059 

Genbank Nucleotide ID

 AAA69971.1; AAA69972.1; AAB08424.1; AAB08424.1; AAB08424.1; AAB08424.1; AAB08425.1; AAB08425.1; AAB08425.1; AAB08425.1; CAI23380.1; EAX07103.1 

Protein Name

 Thrombopoietin receptor 

Protein Synonyms/Alias

 TPO-R; Myeloproliferative leukemia protein; Proto-oncogene c-Mpl; CD110 

Gene Name

 MPL 

Gene Synonyms/Alias

 TPOR 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
553	TAALSPPKATVSDTC	ubiquitination	[1]
573	SLLEILPKSSERTPL	ubiquitination	[1]

Reference

 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses. 

Sequence Annotation

 DOMAIN 133 215 Fibronectin type-III 1.
 DOMAIN 394 481 Fibronectin type-III 2.
 MOTIF 474 478 WSXWS motif.
 MOTIF 528 536 Box 1 motif.
 CARBOHYD 117 117 N-linked (GlcNAc...) (Potential).
 CARBOHYD 178 178 N-linked (GlcNAc...) (Potential).
 CARBOHYD 298 298 N-linked (GlcNAc...) (Potential).
 CARBOHYD 358 358 N-linked (GlcNAc...) (Potential).
 DISULFID 40 50 By similarity.
 DISULFID 77 93 By similarity.
 DISULFID 291 301 By similarity.
 DISULFID 323 334 By similarity.
 CROSSLNK 553 553 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 573 573 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Alternative splicing; Complete proteome; Disease mutation; Disulfide bond; Glycoprotein; Isopeptide bond; Membrane; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 635 AA 

Protein Sequence

Gene Ontology

 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0004896; F:cytokine receptor activity; IEA:InterPro.
 GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
 GO:0008283; P:cell proliferation; TAS:ProtInc.
 GO:0019221; P:cytokine-mediated signaling pathway; IEA:GOC.
 GO:0048872; P:homeostasis of number of cells; IEA:Compara.
 GO:0030168; P:platelet activation; TAS:Reactome.
 GO:0032642; P:regulation of chemokine production; IEA:Compara. 

Interpro

 IPR003961; Fibronectin_type3.
 IPR015152; Growth/epo_recpt_lig-bind.
 IPR013783; Ig-like_fold.
 IPR003528; Long_hematopoietin_rcpt_CS. 

Pfam

 PF09067; EpoR_lig-bind
 PF00041; fn3 

SMART

 SM00060; FN3 

PROSITE

 PS50853; FN3
 PS01352; HEMATOPO_REC_L_F1 

PRINTS