CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036863
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 TRAF-interacting protein 
Protein Synonyms/Alias
  
Gene Name
 TRAIP 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
124STLKKQMKYLEQQQDubiquitination[1]
134EQQQDETKQAQEEARubiquitination[1, 2, 3]
189AVYCVSLKKEYENLKubiquitination[2]
219DLFSSRSKLQTVYSEubiquitination[1]
253KEIMSLKKKLTMLQEubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 266 AA 
Protein Sequence
MPIRALCTIC SDFFDHSRDV AAIHCGHTFH LQCLIQWFET APSRTCPQCR IQEEENVLDA 60
EFLKNELDNV RAQLSQKDKE KRDSQVIIDT LRDTLEERNA TVVSLQQALG KAEMLCSTLK 120
KQMKYLEQQQ DETKQAQEEA RRLRSKMKTM EQIELLLQSQ RPEVEEMIRD MGVGQSAVEQ 180
LAVYCVSLKK EYENLKEARK ASGEVADKLR KDLFSSRSKL QTVYSELDQA KLELKSAQKD 240
LQSADKEIMS LKKKLTMLQE TLNLPP 266 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR009053; Prefoldin.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF13639; zf-RING_2 
SMART
 SM00184; RING 
PROSITE
 PS50089; ZF_RING_2 
PRINTS