CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012743
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Discoidin domain-containing receptor 2 
Protein Synonyms/Alias
 Discoidin domain receptor 2; CD167 antigen-like family member B; Discoidin domain-containing receptor tyrosine kinase 2; Neurotrophic tyrosine kinase, receptor-related 3; Receptor protein-tyrosine kinase TKT; Tyrosine-protein kinase TYRO10; CD167b 
Gene Name
 DDR2 
Gene Synonyms/Alias
 NTRKR3; TKT; TYRO10 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
119IEFAPMYKINYSRDGubiquitination[1]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
 Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. 
Sequence Annotation
 DOMAIN 30 185 F5/8 type C.
 DOMAIN 563 849 Protein kinase.
 NP_BIND 569 577 ATP (By similarity).
 ACT_SITE 710 710 Proton acceptor (By similarity).
 BINDING 608 608 ATP (Probable).
 MOD_RES 461 461 Phosphoserine.
 MOD_RES 471 471 Phosphotyrosine; by SRC and autocatalysis
 MOD_RES 674 674 Phosphoserine.
 MOD_RES 736 736 Phosphotyrosine; by SRC and
 MOD_RES 740 740 Phosphotyrosine; by SRC and
 MOD_RES 741 741 Phosphotyrosine; by SRC and
 CARBOHYD 121 121 N-linked (GlcNAc...) (Potential).
 CARBOHYD 213 213 N-linked (GlcNAc...) (Potential).
 CARBOHYD 261 261 N-linked (GlcNAc...) (Potential).
 CARBOHYD 280 280 N-linked (GlcNAc...) (Potential).
 CARBOHYD 372 372 N-linked (GlcNAc...) (Potential).
 DISULFID 30 185
 DISULFID 73 177  
Keyword
 3D-structure; ATP-binding; Cell membrane; Complete proteome; Disease mutation; Disulfide bond; Dwarfism; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Osteogenesis; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 855 AA 
Protein Sequence
MILIPRMLLV LFLLLPILSS AKAQVNPAIC RYPLGMSGGQ IPDEDITASS QWSESTAAKY 60
GRLDSEEGDG AWCPEIPVEP DDLKEFLQID LHTLHFITLV GTQGRHAGGH GIEFAPMYKI 120
NYSRDGTRWI SWRNRHGKQV LDGNSNPYDI FLKDLEPPIV ARFVRFIPVT DHSMNVCMRV 180
ELYGCVWLDG LVSYNAPAGQ QFVLPGGSII YLNDSVYDGA VGYSMTEGLG QLTDGVSGLD 240
DFTQTHEYHV WPGYDYVGWR NESATNGYIE IMFEFDRIRN FTTMKVHCNN MFAKGVKIFK 300
EVQCYFRSEA SEWEPNAISF PLVLDDVNPS ARFVTVPLHH RMASAIKCQY HFADTWMMFS 360
EITFQSDAAM YNNSEALPTS PMAPTTYDPM LKVDDSNTRI LIGCLVAIIF ILLAIIVIIL 420
WRQFWQKMLE KASRRMLDDE MTVSLSLPSD SSMFNNNRSS SPSEQGSNST YDRIFPLRPD 480
YQEPSRLIRK LPEFAPGEEE SGCSGVVKPV QPSGPEGVPH YAEADIVNLQ GVTGGNTYSV 540
PAVTMDLLSG KDVAVEEFPR KLLTFKEKLG EGQFGEVHLC EVEGMEKFKD KDFALDVSAN 600
QPVLVAVKML RADANKNARN DFLKEIKIMS RLKDPNIIHL LAVCITDDPL CMITEYMENG 660
DLNQFLSRHE PPNSSSSDVR TVSYTNLKFM ATQIASGMKY LSSLNFVHRD LATRNCLVGK 720
NYTIKIADFG MSRNLYSGDY YRIQGRAVLP IRWMSWESIL LGKFTTASDV WAFGVTLWET 780
FTFCQEQPYS QLSDEQVIEN TGEFFRDQGR QTYLPQPAIC PDSVYKLMLS CWRRDTKNRP 840
SFQEIHLLLL QQGDE 855 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005518; F:collagen binding; IDA:UniProtKB.
 GO:0038062; F:protein tyrosine kinase collagen receptor activity; IDA:UniProtKB.
 GO:0031214; P:biomineral tissue development; ISS:UniProtKB.
 GO:0007155; P:cell adhesion; TAS:ProtInc.
 GO:0035988; P:chondrocyte proliferation; ISS:UniProtKB.
 GO:0030199; P:collagen fibril organization; ISS:UniProtKB.
 GO:0003416; P:endochondral bone growth; ISS:UniProtKB.
 GO:0001503; P:ossification; IEA:UniProtKB-KW.
 GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.
 GO:0090091; P:positive regulation of extracellular matrix disassembly; ISS:UniProtKB.
 GO:0010763; P:positive regulation of fibroblast migration; ISS:UniProtKB.
 GO:0048146; P:positive regulation of fibroblast proliferation; ISS:UniProtKB.
 GO:0045669; P:positive regulation of osteoblast differentiation; IMP:UniProtKB.
 GO:0045860; P:positive regulation of protein kinase activity; IMP:UniProtKB.
 GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IMP:UniProtKB.
 GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
 GO:0030500; P:regulation of bone mineralization; IMP:UniProtKB. 
Interpro
 IPR000421; Coagulation_fac_5/8-C_type_dom.
 IPR008979; Galactose-bd-like.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom.
 IPR002011; Tyr_kinase_rcpt_2_CS. 
Pfam
 PF00754; F5_F8_type_C
 PF07714; Pkinase_Tyr 
SMART
 SM00231; FA58C
 SM00219; TyrKc 
PROSITE
 PS01285; FA58C_1
 PS01286; FA58C_2
 PS50022; FA58C_3
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR
 PS00239; RECEPTOR_TYR_KIN_II 
PRINTS
 PR00109; TYRKINASE.