CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013714
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Argininosuccinate synthase 
Protein Synonyms/Alias
 Citrulline--aspartate ligase 
Gene Name
 argG 
Gene Synonyms/Alias
 GK2757 
Created Date
 July 27, 2013 
Organism
 Geobacillus kaustophilus (strain HTA426) 
NCBI Taxa ID
 235909 
Lysine Modification
Position
Peptide
Type
References
47GKDLDFVKEKALKVGacetylation[1]
57ALKVGAMKSYVIDVKacetylation[1]
64KSYVIDVKDEFANEYacetylation[1]
100SRPLIAKKLVEIAELacetylation[1]
328DALVAFLKETQKNVTacetylation[1]
Reference
 [1] Proteomic analysis of acetylation in thermophilic Geobacillus kaustophilus.
 Lee DW, Kim D, Lee YJ, Kim JA, Choi JY, Kang S, Pan JG.
 Proteomics. 2013 Aug;13(15):2278-82. [PMID: 23696451] 
Functional Description
  
Sequence Annotation
 NP_BIND 9 17 ATP (By similarity).
 BINDING 86 86 Citrulline (By similarity).
 BINDING 116 116 ATP; via amide nitrogen (By similarity).
 BINDING 118 118 Aspartate (By similarity).
 BINDING 122 122 Aspartate (By similarity).
 BINDING 122 122 Citrulline (By similarity).
 BINDING 123 123 Aspartate (By similarity).
 BINDING 126 126 Citrulline (By similarity).
 BINDING 174 174 Citrulline (By similarity).
 BINDING 183 183 Citrulline (By similarity).
 BINDING 259 259 Citrulline (By similarity).
 BINDING 271 271 Citrulline (By similarity).  
Keyword
 Amino-acid biosynthesis; Arginine biosynthesis; ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 406 AA 
Protein Sequence
MANPKLVLAY SGGLDTSVAI KWLQERGYDV IACCLDLGEG KDLDFVKEKA LKVGAMKSYV 60
IDVKDEFANE YALIALQANA LYEGKYPLVS ALSRPLIAKK LVEIAELEGA VAVAHGCTGK 120
GNDQVRFEVS IKALNPDLDV IAPVREWSWS REEEIEYAKK HGIPIPVDLD SPFSIDQNLW 180
GRSNECGILE DPWAAPPEEA YELTASLENA PDVPDVIEIG FEQGVPVTLN GKAYPLAQLI 240
LELNALAGKH GVGRIDHVEN RLVGIKSREV YECPGAITLI KAHKELEDLT LVREVAHFKP 300
IIEQKIAEVI YNGLWFSPLK DALVAFLKET QKNVTGVVRV KLFKGHAIVE GRKSPFSLYD 360
EKLATYTSED EFDHQAAVGF ISLYGLPTKV HSIVNKQNKA SVPTGQ 406 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004055; F:argininosuccinate synthase activity; IEA:HAMAP.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0006526; P:arginine biosynthetic process; IEA:HAMAP. 
Interpro
 IPR001518; Arginosuc_synth.
 IPR018223; Arginosuc_synth_CS.
 IPR023434; Arginosuc_synth_type_1_subfam.
 IPR024074; AS_cat/multimer_dom_body.
 IPR014729; Rossmann-like_a/b/a_fold. 
Pfam
 PF00764; Arginosuc_synth 
SMART
  
PROSITE
 PS00564; ARGININOSUCCIN_SYN_1
 PS00565; ARGININOSUCCIN_SYN_2 
PRINTS