CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004762
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Porphobilinogen deaminase 
Protein Synonyms/Alias
 PBG-D; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase 
Gene Name
 Hmbs 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
74ALSKIGEKSLFTKELacetylation[1]
132FHPKFIGKTLETLPEacetylation[1]
164KFPHLEFKSIRGNLNacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. 
Sequence Annotation
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 261 261 S-(dipyrrolylmethanemethyl)cysteine (By  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Heme biosynthesis; Porphyrin biosynthesis; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 361 AA 
Protein Sequence
MSGNGGAATT AEENGSMMRV IRVGTRKSQL ARIQTDTVVA MLKTLYPGIQ FEIIAMSTTG 60
DKILDTALSK IGEKSLFTKE LENALEKNEV DLVVHSLKDV PTILPPGFTI GAICKRENPC 120
DAVVFHPKFI GKTLETLPEK SAVGTSSLRR VAQLQRKFPH LEFKSIRGNL NTRLRKLDEQ 180
LEFSAIILAV AGLQRMGWQN RVGQILHPEE CMYAVGQGAL AVEVRAKDQD ILDLVGVLHD 240
PETLLRCIAE RAFLRHLEGG CSVPVAVHTV MKDGQLYLTG GVWSLDGSDS MQETMQATIQ 300
VPVQQEDGPE DDPQLVGITA RNIPRGAQLA AENLGISLAS LLLNKGAKNI LDVARQLNDV 360
R 361 
Gene Ontology
 GO:0030424; C:axon; IDA:RGD.
 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0043176; F:amine binding; IPI:RGD.
 GO:0031406; F:carboxylic acid binding; IPI:RGD.
 GO:0050662; F:coenzyme binding; IPI:RGD.
 GO:0004418; F:hydroxymethylbilane synthase activity; IDA:RGD.
 GO:0004852; F:uroporphyrinogen-III synthase activity; IDA:RGD.
 GO:0048708; P:astrocyte differentiation; IEP:RGD.
 GO:0071418; P:cellular response to amine stimulus; IEP:RGD.
 GO:0071236; P:cellular response to antibiotic; IEP:RGD.
 GO:0071243; P:cellular response to arsenic-containing substance; IEP:RGD.
 GO:0071345; P:cellular response to cytokine stimulus; IEP:RGD.
 GO:0071549; P:cellular response to dexamethasone stimulus; IEP:RGD.
 GO:0071284; P:cellular response to lead ion; IEP:RGD.
 GO:0031100; P:organ regeneration; IEP:RGD.
 GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
 GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0043200; P:response to amino acid stimulus; IEP:RGD.
 GO:0009743; P:response to carbohydrate stimulus; IEP:RGD.
 GO:0032025; P:response to cobalt ion; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0032355; P:response to estradiol stimulus; IEP:RGD.
 GO:0001666; P:response to hypoxia; IEP:RGD.
 GO:0051597; P:response to methylmercury; IEP:RGD.
 GO:0033273; P:response to vitamin; IEP:RGD.
 GO:0010043; P:response to zinc ion; IEP:RGD.
 GO:0033014; P:tetrapyrrole biosynthetic process; IDA:RGD. 
Interpro
 IPR000860; 4pyrrol_synth_OHMeBilane_synth.
 IPR022419; Porphobilin_deaminase_cofac_BS.
 IPR022417; Porphobilin_deaminase_N.
 IPR022418; Porphobilinogen_deaminase_C. 
Pfam
 PF01379; Porphobil_deam
 PF03900; Porphobil_deamC 
SMART
  
PROSITE
 PS00533; PORPHOBILINOGEN_DEAM 
PRINTS
 PR00151; PORPHBDMNASE.