CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010920
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 CRE-binding bZIP protein SKO1 
Protein Synonyms/Alias
  
Gene Name
 SKO1 
Gene Synonyms/Alias
 ACR1; YNL167C; N1702 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
47ISHPSLPKELSRNNSacetylation[1]
585SRPIILDKKYSLNSGacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Binds to the CRE motif 5'-TGACGTCA-3' and acts as a repressor of transcription of the SUC2 gene and most probably other genes. 
Sequence Annotation
 DOMAIN 429 492 bZIP.
 REGION 430 451 Basic motif (By similarity).
 REGION 454 461 Leucine-zipper (By similarity).
 MOD_RES 94 94 Phosphoserine.
 MOD_RES 113 113 Phosphothreonine.
 MOD_RES 399 399 Phosphoserine.
 MOD_RES 558 558 Phosphoserine.  
Keyword
 Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 647 AA 
Protein Sequence
MSSEERSRQP STVSTFDLEP NPFEQSFASS KKALSLPGTI SHPSLPKELS RNNSTSTITQ 60
HSQRSTHSLN SIPEENGNST VTDNSNHNDV KKDSPSFLPG QQRPTIISPP ILTPGGSKRL 120
PPLLLSPSIL YQANSTTNPS QNSHSVSVSN SNPSAIGVSS TSGSLYPNSS SPSGTSLIRQ 180
PRNSNVTTSN SGNGFPTNDS QMPGFLLNLS KSGLTPNESN IRTGLTPGIL TQSYNYPVLP 240
SINKNTITGS KNVNKSVTVN GSIENHPHVN IMHPTVNGTP LTPGLSSLLN LPSTGVLANP 300
VFKSTPTTNT TDGTVNNSIS NSNFSPNTST KAAVKMDNPA EFNAIEHSAH NHKENENLTT 360
QIENNDQFNN KTRKRKRRMS STSSTSKASR KNSISRKNSA VTTAPAQKDD VENNKISNNV 420
TLDENEEQER KRKEFLERNR VAASKFRKRK KEYIKKIEND LQFYESEYDD LTQVIGKLCG 480
IIPSSSSNSQ FNVNVSTPSS SSPPSTSLIA LLESSISRSD YSSAMSVLSN MKQLICETNF 540
YRRGGKNPRD DMDGQEDSFN KDTNVVKSEN AGYPSVNSRP IILDKKYSLN SGANISKSNT 600
TTNNVGNSAQ NIINSCYSVT NPLVINANSD THDTNKHDVL STLPHNN 647 
Gene Ontology
 GO:0005829; C:cytosol; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0051019; F:mitogen-activated protein kinase binding; IDA:SGD.
 GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IDA:SGD.
 GO:0001078; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; IMP:SGD.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IMP:SGD.
 GO:0001103; F:RNA polymerase II repressing transcription factor binding; IDA:SGD.
 GO:0001191; F:RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription; IMP:SGD.
 GO:0001133; F:sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity; IMP:SGD.
 GO:0061393; P:positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress; IMP:SGD. 
Interpro
 IPR004827; bZIP.
 IPR020956; TF_Aft1_OSM. 
Pfam
 PF11785; Aft1_OSA
 PF00170; bZIP_1 
SMART
 SM00338; BRLZ 
PROSITE
 PS50217; BZIP
 PS00036; BZIP_BASIC 
PRINTS