CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011751
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 pH-response regulator protein palA/RIM20 
Protein Synonyms/Alias
 Regulator of IME2 protein 20 
Gene Name
 RIM20 
Gene Synonyms/Alias
 YOR275C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
232INHLKAKKAYFSAVTacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Required for the proteolytic cleavage of the transcriptional repressor RIM101 in response to alkaline ambient pH, which is necessary for sporulation and invasive growth. May act as a scaffold protein that recruits the calpain-like protease RIM13 via SNF7 to its substrate RIM101. 
Sequence Annotation
 DOMAIN 3 371 BRO1.  
Keyword
 Coiled coil; Complete proteome; Cytoplasm; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 661 AA 
Protein Sequence
MSELLAIPLK RTLEVDFATE LSKLIDTTSF QTASFFQSDI LKVVDARNNA IAPDISIDGL 60
SALKEYYVIL LQLEKKFPNN QIEFTWFQTL SQKSRGTSQY SLQWEKLTII YNIGCMYSLL 120
ALNSNNDAAE SLKTSCLYFQ NAAGCFKHVL DHQKNLETIP VVDDATLNAL TSLMLAQAQE 180
CFWFKAVQDK HKDSLIAKLS QQIVDFYCEA INDAQRGKLI RSDWINHLKA KKAYFSAVTY 240
YRIALSFNEK KQFGNVVKAL QMGLQFINES TLSSQAKFKT VVESSLKEAQ RDNEFIYLQE 300
VPSELPSIKP ALMVKPSSSA TLLPSIKKDE TLFKDLIPIE VMEYCTAYNE RQDEYVEQRV 360
TNPLASLNKL LKESLTTFQI PQGLTKVSEA ELSHYQASLN NLLINNKNVQ VQLDNIEQIL 420
NEEAFTDNQL RLKHGTLNWT LPESSTTNTA YYEKLKKLRG YLDEGSAIDK QTNELFQSID 480
KNLIGSEIRL PESNDPLTNK IKMIIQERND YIDRTRRKSS EYRILPKIIT SYKKNGTVDF 540
EPIFIGHLKY FDEDLRYVNS TKEENIKLIE EVNLSKKNNP GRSGIEPKKM VRIDPRELYI 600
EDLRYSFKLL DEVKENLSAG TAFYENLITS TSNLYNEVQE YDTARRAEKA RLDKSLTFED 660
Q 661 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0001403; P:invasive growth in response to glucose limitation; IMP:SGD.
 GO:0016485; P:protein processing; IGI:SGD.
 GO:0006508; P:proteolysis; IMP:SGD.
 GO:0009268; P:response to pH; IMP:SGD.
 GO:0030435; P:sporulation resulting in formation of a cellular spore; IMP:SGD. 
Interpro
 IPR025304; ALIX_V_dom.
 IPR004328; BRO1_dom. 
Pfam
 PF13949; ALIX_LYPXL_bnd
 PF03097; BRO1 
SMART
 SM01041; BRO1 
PROSITE
 PS51180; BRO1 
PRINTS