CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036884
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 E3 ubiquitin-protein ligase CBL-B 
Protein Synonyms/Alias
  
Gene Name
 CBLB 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
859RLPGENVKTNRTSQDubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 960 AA 
Protein Sequence
MALAPGPDAH AHLPPLIELK FQMANSMNGR NPGGRGGNPR KGRILGIIDA IQDAVGPPKQ 60
AAADRRTVEK TWKLMDKVVR LCQNPKLQLK NSPPYILDIL PDTYQHLRLI LSKYDDNQKL 120
AQLSENEYFK IYIDSLMKKS KRAIRLFKEG KERMYEEQSQ DRRNLTKLSL IFSHMLAEIK 180
AIFPNGQFQG DNFRITKADA AEFWRKFFGD KTIVPWKVFR QCLHEVHQIS SGLEAMALKS 240
TIDLTCNDYI SVFEFDIFTR LFQPWGSILR NWNFLAVTHP GYMAFLTYDE VKARLQKYST 300
KPGSYIFRLS CTRLGQWAIG YVTGDGNILQ TIPHNKPLFQ ALIDGSREGF YLYPDGRSYN 360
PDLTGLCEPT PHDHIKVTQE QYELYCEMGS TFQLCKICAE NDKDVKIEPC GHLMCTSCLT 420
AWQESDGQGC PFCRCEIKGT EPIIVDPFDP RDEGSRCCSI IDPFGMPMLD LDDDDDREES 480
LMMNRLANVR KCTDRQNSPV TSPGSSPLAQ RRKPQPDPLQ IPHLSLPPVP PRLDLIQKGI 540
VRSPCGSPTG SPKSSPCMVR KQDKPLPAPP PPLRDPPPPP PERPPPIPPD NRLSRHIHHV 600
ESVPSRDPPM PLEAWCPRDV FGTNQLVGCR LLGEGSPKPG ITASSNVNGR HSRVGSDPVL 660
MRKHRRHDLP LEGAKVFSNG HLGSEEYDVP PRLSPPPPVT TLLPSIKCTG PLANSLSEKT 720
RDPVEEDDDE YKIPSSHPVS LNSQPSHCHN VKPPVRSCDN GHCMLNGTHG PSSEKKSNIP 780
DLSIYLKGED AFDALPPSLP PPPPPARHSL IEHSKPPGSS SRPSSGQDLF LLPSDPFVDL 840
ASGQVPLPPA RRLPGENVKT NRTSQDYDQL PSCSDGSQAP ARPPKPRPRR TAPEIHHRKP 900
HGPEAALENV DAKIAKLMGE GYAFEEVKRA LEIAQNNVEV ARSILREFAF PPPVSPRLNL 960 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
 GO:0016567; P:protein ubiquitination; IEA:GOC.
 GO:0023051; P:regulation of signaling; IEA:InterPro. 
Interpro
 IPR024162; Adaptor_Cbl.
 IPR014741; Adaptor_Cbl_EF_hand-like.
 IPR003153; Adaptor_Cbl_N_hlx.
 IPR014742; Adaptor_Cbl_SH2-like.
 IPR024159; Cbl_PTB.
 IPR011992; EF-hand-like_dom.
 IPR000980; SH2.
 IPR000449; UBA/transl_elong_EF1B_N.
 IPR015940; UBA/transl_elong_EF1B_N_euk.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 
Pfam
 PF02262; Cbl_N
 PF02761; Cbl_N2
 PF02762; Cbl_N3
 PF00627; UBA 
SMART
 SM00184; RING
 SM00252; SH2
 SM00165; UBA 
PROSITE
 PS51506; CBL_PTB
 PS50030; UBA
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS