Tag | Content |
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CPLM ID | CPLM-010698 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Long-chain fatty acid transport protein 1 |
Protein Synonyms/Alias | FATP-1; Fatty acid transport protein 1; Solute carrier family 27 member 1 |
Gene Name | Slc27a1 |
Gene Synonyms/Alias | Fatp; Fatp1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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624 | RLFFLDLKQGRYLPL | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of Fatp1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane- associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (By similarity). |
Sequence Annotation | NP_BIND 246 257 AMP (By similarity). REGION 191 475 Sufficient for oligomerization (By |
Keyword | Cell membrane; Complete proteome; Cytoplasm; Fatty acid metabolism; Ligase; Lipid metabolism; Lipid transport; Membrane; Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 646 AA |
Protein Sequence | MRTPGAGTAS VASLGLLWLL GLPWTWSAAA AFGVYVGSGG WRFLRIVCKT ARRDLFGLSV 60 LIRVRLELRR HRRAGDTIPR IFQAVAQRQP ERLALVDASS GICWTFAQLD TYSNAVANLF 120 LQLGFAPGDV VAVFLEGRPE FVGLWLGLAK AGVVAALLNV NLRREPLAFC LGTSAAKALI 180 YGGEMAAAVA EVSEQLGKSL LKFCSGDLGP ESVLPDTQLL DPMLAEAPTT PLAQAPGKGM 240 DDRLFYIYTS GTTGLPKAAI VVHSRYYRIA AFGHHSYSMR ANDVLYDCLP LYHSAGNIMG 300 VGQCIIYGLT VVLRKKFSAS RFWDDCVKYN CTVVQYIGEI CRYLLRQPVR DVERRHRVRL 360 AVGNGLRPAI WEEFTQGFGV RQIGEFYGAT ECNCSIANMD GKVGSCGFNS RILTHVYPIR 420 LVKVNEDTME PLRDSQGLCI PCQPGEPGLL VGQINQQDPL RRFDGYVSDS ATNKKIAHSV 480 FRKGDSAYLS GDVLVMDELG YMYFRDRSGD TFRWRGENVS TTEVEAVLSR LLGQTDVAVY 540 GVAVPGVEGK SGMAAIADPH NQLDPNSMYQ ELQKVLASYA QPIFLRLLPQ VDTTGTFKIQ 600 KTRLQREGFD PRQTSDRLFF LDLKQGRYLP LDERVHARIC AGDFSL 646 |
Gene Ontology | GO:0005901; C:caveola; IDA:RGD. GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005739; C:mitochondrion; IDA:RGD. GO:0015245; F:fatty acid transporter activity; NAS:RGD. GO:0016874; F:ligase activity; IEA:UniProtKB-KW. GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW. GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW. |
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