UniProt Accession

 PGPS1_HUMAN; Q32NB8; B7ZA32; Q8IYK9; Q8TA85; Q96A75; Q9H7G9; Q9NPW7 

Genbank Protein ID

 AK024529; AK316147; CH471099; BC008903; BC015570; BC025951; BC035662; BC108732; AL359590; CR749720 

Genbank Nucleotide ID

 BAB14921.1; BAH14518.1; EAW89524.1; AAH08903.2; AAH15570.2; AAH25951.2; AAH35662.1; AAI08733.1; CAB94876.1; CAH18487.1 

Protein Name

 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial 

Protein Synonyms/Alias

 Phosphatidylglycerophosphate synthase 1; PGP synthase 1 

Gene Name

 PGS1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
152	LEKSLQAKFPSNLKV	ubiquitination	[1, 2, 3]
553	KMVTPLIKNFF****	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin (By similarity). 

Sequence Annotation

 DOMAIN 215 241 PLD phosphodiesterase 1.
 DOMAIN 460 493 PLD phosphodiesterase 2.
 NP_BIND 124 131 ATP (Potential).
 ACT_SITE 220 220 Potential.
 ACT_SITE 222 222 Potential.
 ACT_SITE 227 227 Potential.  

Keyword

 Alternative splicing; ATP-binding; Complete proteome; Lipid biosynthesis; Lipid metabolism; Mitochondrion; Nucleotide-binding; Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome; Repeat; Transferase; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 556 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IDA:LIFEdb.
 GO:0005743; C:mitochondrial inner membrane; TAS:BHF-UCL.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005509; F:calcium ion binding; ISS:BHF-UCL.
 GO:0008444; F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity; ISS:BHF-UCL.
 GO:0032049; P:cardiolipin biosynthetic process; ISS:BHF-UCL.
 GO:0046339; P:diacylglycerol metabolic process; ISS:BHF-UCL.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR025202; PLD-like_dom.
 IPR016270; PLipase-D_PtdSer-synthase-type.
 IPR001736; PLipase_D/transphosphatidylase. 

Pfam

 PF13091; PLDc_2 

SMART

  

PROSITE

 PS50035; PLD 

PRINTS