CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039528
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Probable global transcription activator SNF2L2 
Protein Synonyms/Alias
  
Gene Name
 Smarca2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
344SRISPIQKPQGLDPVubiquitination[1]
424LETALNSKAYKRSKRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Bromodomain; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1583 AA 
Protein Sequence
MSTPTDPAAM PHPGPSPGPG PSPGPILGPS PGPGPSPGSV HSMMGPSPGP PSVSHPLSTM 60
GSADFPQEGM HQLHKPMDGI HDKGIVEDVH CGSMKGTSMR PPHPGMGPPQ SPMDQHSQGY 120
MSPHPSPLGA PEHVSSPISG GGPTPPQMPP SQPGALIPGD PQAMNQPNRG PSPFSPVQLH 180
QLRAQILAYK MLARGQPLPE TLQLAVQGKR TLPGMQQQQQ QQQQQQQQQQ QQQQQQQQQQ 240
QPQQPQQQAQ AQPQQQQQQQ QQPALVSYNR PSGPGQELLL SGQSAPQKLS APAPSGRPSP 300
APQAAVQPTA TAVPGPSVQQ PAPGQPSPVL QLQQKQSRIS PIQKPQGLDP VEILQEREYR 360
LQARIAHRIQ ELESLPGSLP PDLRTKATVE LKALRLLNFQ RQLRQEVVAC MRRDTTLETA 420
LNSKAYKRSK RQTLREARMT EKLEKQQKIE QERKRRQKHQ EYLNSILQHA KDFKEYHRSV 480
AGKIQKLSKA VATWHANTER EQKKETERIE KERMRRLMAE DEEGYRKLID QKKDRRLAYL 540
LQQTDEYVAN LTNLVWEHKQ AQAAKEKKKR RRRKKKAEEN AEGGEPALGP DGEPIDESSQ 600
MSDLPVKVTH TETGKVLFGP EAPKASQLDA WLEMNPGYEV APRSDSEESE SDYEEEDEEE 660
ESSRQETEEK ILLDPNSEEV SEKDAKQIIE TAKQDVDDEY SMQYSARGSQ SYYTVAHAIS 720
ERVEKQSALL INGTLKHYQL QGLEWMVSLY NNNLNGILAD EMGLGKTIQT IALITYLMEH 780
KRLNGPYLII VPLSTLSNWT YEFDKWAPSV VKISYKGTPA MRRSLVPQLR SGKFNVLLTT 840
YEYIIKDKHI LAKIRWKYMI VDEGHRMKNH HCKLTQVLNT HYVAPRRILL TGTPLQNKLP 900
ELWALLNFLL PTIFKSCSTF EQWFNAPFAM TGERVDLNEE ETILIIRRLH KVLRPFLLRR 960
LKKEVESQLP EKVEYVIKCD MSALQKILYR HMQAKGILLT DGSEKDKKGK GGAKTLMNTI 1020
MQLRKICNHP YMFQHIEESF AEHLGYSNGV INGAELYRAS GKFELLDRIL PKLRATNHRV 1080
LLFCQMTSLM TIMEDYFAFR NFLYLRLDGT TKSEDRAALL KKFNEPGSQY FIFLLSTRAG 1140
GLGLNLQAAD TVVIFDSDWN PHQDLQAQDR AHRIGQQNEV RVLRLCTVNS VEEKILAAAK 1200
YKLNVDQKVI QAGMFDQKSS SHERRAFLQA ILEHEEENEE EDEVPDDETL NQMIARREEE 1260
FDLFMRMDMD RRREDARNPK RKPRLMEEDE LPSWIIKDDA EVERLTCEEE EEKIFGRGSR 1320
QRRDVDYSDA LTEKQWLRAI EDGNLEEMEE EVRLKKRKRR RNVDKDPVKE DVEKAKKRRG 1380
RPPAEKLSPN PPKLTKQMNA IIDTVINYKD SSGRQLSEVF IQLPSRKDLP EYYELIRKPV 1440
DFKKIKERIR NHKYRSLGDL EKDVMLLCHN AQTFNLEGSQ IYEDSIVLQS VFKSARQKIA 1500
KEEESEEESN EEEEEDDEEE SESEAKSVKV KIKLNKKEEK GRDTGKGKKR PNRGKAKPVV 1560
SDFDSDEEQE ENEQSEASGT DNE 1583 
Gene Ontology
 GO:0045111; C:intermediate filament cytoskeleton; IEA:Compara.
 GO:0000790; C:nuclear chromatin; IEA:Compara.
 GO:0016514; C:SWI/SNF complex; TAS:MGI.
 GO:0071778; C:WINAC complex; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004386; F:helicase activity; IEA:InterPro.
 GO:0001105; F:RNA polymerase II transcription coactivator activity; IEA:Compara.
 GO:0044212; F:transcription regulatory region DNA binding; IEA:Compara.
 GO:0035887; P:aortic smooth muscle cell differentiation; IMP:MGI.
 GO:0030308; P:negative regulation of cell growth; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; IMP:MGI.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0006334; P:nucleosome assembly; TAS:MGI. 
Interpro
 IPR006576; BRK_domain.
 IPR001487; Bromodomain.
 IPR018359; Bromodomain_CS.
 IPR014978; Gln-Leu-Gln_QLQ.
 IPR013999; HAS_subgr.
 IPR014012; Helicase/SANT-assoc_DNA-bd.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR006562; HSA.
 IPR027417; P-loop_NTPase.
 IPR000330; SNF2_N. 
Pfam
 PF07533; BRK
 PF00439; Bromodomain
 PF00271; Helicase_C
 PF07529; HSA
 PF00176; SNF2_N 
SMART
 SM00592; BRK
 SM00297; BROMO
 SM00487; DEXDc
 SM00490; HELICc
 SM00573; HSA
 SM00951; QLQ 
PROSITE
 PS00633; BROMODOMAIN_1
 PS50014; BROMODOMAIN_2
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER
 PS51204; HSA 
PRINTS
 PR00503; BROMODOMAIN.