UniProt Accession

 NKD2_HUMAN; Q969F2; Q96EK8; Q9BSN0 

Genbank Protein ID

 AF358137; AB062887; BC004940; BC012176 

Genbank Nucleotide ID

 AAK57486.1; BAB70501.1; AAH04940.1; AAH12176.1 

Protein Name

 Protein naked cuticle homolog 2 

Protein Synonyms/Alias

 Naked-2; hNkd2 

Gene Name

 NKD2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
74	QVALPAEKAEGREHP	ubiquitination	[1]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells. 

Sequence Annotation

 DOMAIN 119 154 EF-hand.
 REGION 2 173 Targeting to the basolateral cell
 REGION 113 178 Interaction with DVL1, DVL2 and DVL3 (By
 REGION 300 385 Interaction with TGFA.
 LIPID 2 2 N-myristoyl glycine.  

Keyword

 Alternative splicing; Calcium; Cell membrane; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Exocytosis; Lipoprotein; Membrane; Metal-binding; Myristate; Polymorphism; Reference proteome; Transport; Ubl conjugation; Wnt signaling pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 451 AA 

Protein Sequence

Gene Ontology

 GO:0016323; C:basolateral plasma membrane; IDA:BHF-UCL.
 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
 GO:0031410; C:cytoplasmic vesicle; IDA:BHF-UCL.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
 GO:0048210; P:Golgi vesicle fusion to target membrane; IMP:BHF-UCL.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IDA:BHF-UCL.
 GO:0090004; P:positive regulation of establishment of protein localization to plasma membrane; IDA:BHF-UCL.
 GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IMP:BHF-UCL.
 GO:0010954; P:positive regulation of protein processing; IDA:BHF-UCL.
 GO:0072661; P:protein targeting to plasma membrane; IMP:BHF-UCL.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR002048; EF_hand_dom. 

Pfam

  

SMART

  

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 

PRINTS