UniProt Accession

 YAFN_ECOLI; Q47156; Q2MCF9 

Genbank Protein ID

 D38582; U70214; U00096; AP009048 

Genbank Nucleotide ID

 BAA07594.1; AAB08652.1; AAC73336.1; BAE76047.1 

Protein Name

 Antitoxin YafN 

Protein Synonyms/Alias

  

Gene Name

 yafN 

Gene Synonyms/Alias

 b0232; JW0222 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
8	MHRILAEKSVNITEL	acetylation	[1]
96	DDDFNDFKE******	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin; overexpression prevents YafO-mediated cessation of cell growth and inhibition of cell proliferation. 

Sequence Annotation

  

Keyword

 Complete proteome; DNA damage; DNA repair; DNA-binding; Reference proteome; Repressor; SOS response; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 97 AA 

Protein Sequence

Gene Ontology

 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0044092; P:negative regulation of molecular function; IDA:EcoCyc.
 GO:0006355; P:regulation of transcription, DNA-dependent; IMP:EcoCyc.
 GO:0006974; P:response to DNA damage stimulus; IEP:EcoliWiki.
 GO:0009432; P:SOS response; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR006442; Antitoxin_Phd/YefM. 

Pfam

 PF02604; PhdYeFM_antitox 

SMART

  

PROSITE

  

PRINTS