| Tag | Content |
|---|
| CPLM ID | CPLM-017524 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | N-acetylaspartate synthetase |
Protein Synonyms/Alias | NAA synthetase; Camello-like protein 3; N-acetyltransferase 8-like protein |
Gene Name | NAT8L |
Gene Synonyms/Alias | CML3 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 257 | AVKVAAHKLYESLGF | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake. |
Sequence Annotation | DOMAIN 143 283 N-acetyltransferase. |
Keyword | Acyltransferase; Complete proteome; Cytoplasm; Endoplasmic reticulum; Membrane; Microsome; Mitochondrion; Reference proteome; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 302 AA |
Protein Sequence | MHCGPPDMVC ETKIVAAEDH EALPGAKKDA LLAAAGAMWP PLPAAPGPAA APPAPPPAPV 60
AQPHGGAGGA GPPGGRGVCI REFRAAEQEA ARRIFYDGIM ERIPNTAFRG LRQHPRAQLL 120
YALLAALCFA VSRSLLLTCL VPAALLGLRY YYSRKVIRAY LECALHTDMA DIEQYYMKPP 180
GSCFWVAVLD GNVVGIVAAR AHEEDNTVEL LRMSVDSRFR GKGIAKALGR KVLEFAVVHN 240
YSAVVLGTTA VKVAAHKLYE SLGFRHMGAS DHYVLPGMTL SLAERLFFQV RYHRYRLQLR 300
EE 302 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0031966; C:mitochondrial membrane; IDA:UniProtKB. GO:0030867; C:rough endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0017188; F:aspartate N-acetyltransferase activity; IDA:UniProtKB. GO:0051586; P:positive regulation of dopamine uptake involved in synaptic transmission; IEA:Compara. |
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