CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011481
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glucokinase regulatory protein 
Protein Synonyms/Alias
 Glucokinase regulator 
Gene Name
 Gckr 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
164LHGIEELKKVAAGKKacetylation[1]
279TLLLAAHKTVDQGVVacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Inhibits glucokinase by forming an inactive complex with this enzyme. 
Sequence Annotation
 DOMAIN 90 286 SIS 1.
 DOMAIN 320 499 SIS 2.  
Keyword
 Complete proteome; Direct protein sequencing; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 627 AA 
Protein Sequence
MPGTKRYQHV IETPEPGEWE LSGYEAAVPI TEKSNPLTRN LDKADAEKIV KLLGQCDAEI 60
FQEEGQIVPT YQRLYSESVL TTMLQVAGKV QEVLKEPDGG LVVLSGGGTS GRMAFLMSVS 120
FNQLMKGLGQ KPLYTYLIAG GDRSVVASRE QTEDSALHGI EELKKVAAGK KRVVVIGISV 180
GLSAPFVAGQ MDYCMDNTAV FLPVLVGFNP VSMARNDPIE DWRSTFRQVA ERMQKMQEKQ 240
EAFVLNPAIG PEGLSGSSRM KGGGATKILL ETLLLAAHKT VDQGVVSSQR CLLEILRTFE 300
RAHQVTYSQS SKIATLMKQV GISLEKKGRV HLVGWQTLGI IAIMDGVECI HTFGADFQDI 360
RGFLIGDHSD MFNQKDELTN QGPQFTFSQD DFLTSILPSL TETDTVVFIF TLDDNLTEVQ 420
ALAERVREKC QNIQALVHST VGQSLPAPLK KLFPSLISIT WPLLFFDYEG TYVQKFQREL 480
STKWVLNTVS TGAHVLLGKI LQNHMLDLRI ANSKLFWRAL AMLQRFSGQS KARCIESLLQ 540
AIHFPQPLSD DVRAAPISCH VQVAHEKEKV IPTALLSLLL RCSISEAKAR LSAASSVCEV 600
VRSALSGPGQ KRSTQALEDP PACGTLN 627 
Gene Ontology
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005739; C:mitochondrion; IDA:RGD.
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0030246; F:carbohydrate binding; IDA:RGD.
 GO:0019899; F:enzyme binding; IMP:RGD.
 GO:0004857; F:enzyme inhibitor activity; IDA:RGD.
 GO:0070095; F:fructose-6-phosphate binding; IEA:Compara.
 GO:0001678; P:cellular glucose homeostasis; IEA:Compara.
 GO:0051594; P:detection of glucose; NAS:BHF-UCL.
 GO:0006006; P:glucose metabolic process; TAS:RGD.
 GO:0033132; P:negative regulation of glucokinase activity; IDA:BHF-UCL.
 GO:0033133; P:positive regulation of glucokinase activity; IEA:Compara.
 GO:0000060; P:protein import into nucleus, translocation; IDA:BHF-UCL.
 GO:0009750; P:response to fructose stimulus; IDA:BHF-UCL.
 GO:0070328; P:triglyceride homeostasis; IEA:Compara.
 GO:0046415; P:urate metabolic process; IEA:Compara. 
Interpro
 IPR005486; Glucokinase_regulatory_CS.
 IPR001347; SIS. 
Pfam
  
SMART
  
PROSITE
 PS01272; GCKR
 PS51464; SIS 
PRINTS