| Tag | Content |
|---|
| CPLM ID | CPLM-001490 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | SUN domain-containing protein 1 |
Protein Synonyms/Alias | Protein unc-84 homolog A; Sad1/unc-84 protein-like 1 |
Gene Name | SUN1 |
Gene Synonyms/Alias | KIAA0810; UNC84A |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 109 | LDDDGDLKGGNKAAI | ubiquitination | [1] | | 257 | DDPQDVFKPTTSRLK | ubiquitination | [1] | | 309 | ELTTLLQKLQARVDQ | ubiquitination | [1] | | 461 | FSSQFVSKGDLQTML | ubiquitination | [1] | | 527 | LKLYSQDKTGMVDFA | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non- coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity). |
Sequence Annotation | DOMAIN 649 811 SUN.
REGION 1 138 LMNA-binding.
REGION 209 302 SYNE2-binding.
REGION 223 302 EMD-binding.
MOD_RES 48 48 Phosphoserine (By similarity).
MOD_RES 52 52 Phosphoserine (By similarity).
MOD_RES 100 100 Phosphoserine.
MOD_RES 138 138 Phosphoserine. |
Keyword | Alternative splicing; Coiled coil; Complete proteome; Membrane; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 812 AA |
Protein Sequence | MSRRSLRLAT TACTLGDGEA VGADSGTSSA VSLKNRAART TKQRRSTNKS AFSINHVSRQ 60
VTSSGVSHGG TVSLQDAVTR RPPVLDESWI REQTTVDHFW GLDDDGDLKG GNKAAIQGNG 120
DVGAAAATAH NGFSCSNCSM LSERKDVLTA HPAAPGPVSR VYSRDRNQKW KAASGVFWWL 180
GIGWYQFVTL ISWLNVFLLT RCLRNICKFL VLLIPLFLLL AGLSLRGQGN FFSFLPVLNW 240
ASMHRTQRVD DPQDVFKPTT SRLKQPLQGD SEAFPWHWMS GVEQQVASLS GQCHHHGENL 300
RELTTLLQKL QARVDQMEGG AAGPSASVRD AVGQPPRETD FMAFHQEHEV RMSHLEDILG 360
KLREKSEAIQ KELEQTKQKT ISAVGEQLLP TVEHLQLELD QLKSELSSWR HVKTGCETVD 420
AVQERVDVQV REMVKLLFSE DQQGGSLEQL LQRFSSQFVS KGDLQTMLRD LQLQILRNVT 480
HHVSVTKQLP TSEAVVSAVS EAGASGITEA QARAIVNSAL KLYSQDKTGM VDFALESGGG 540
SILSTRCSET YETKTALMSL FGIPLWYFSQ SPRVVIQPDI YPGNCWAFKG SQGYLVVRLS 600
MMIHPAAFTL EHIPKTLSPT GNISSAPKDF AVYGLENEYQ EEGQLLGQFT YDQDGESLQM 660
FQALKRPDDT AFQIVELRIF SNWGHPEYTC LYRFRVHGEP VK 702 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell. GO:0031965; C:nuclear membrane; IDA:HPA. GO:0034993; C:SUN-KASH complex; IDA:UniProtKB. GO:0090286; P:cytoskeletal anchoring at nuclear membrane; IDA:UniProtKB. GO:0006998; P:nuclear envelope organization; IGI:MGI. GO:0090292; P:nuclear matrix anchoring at nuclear membrane; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |