UniProt Accession

 MITD1_HUMAN; Q8WV92; Q69YV0 

Genbank Protein ID

 AC092587; BC018453; AL161992 

Genbank Nucleotide ID

 AAX88928.1; AAH18453.1; CAH10777.1 

Protein Name

 MIT domain-containing protein 1 

Protein Synonyms/Alias

  

Gene Name

 MITD1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
67	NLREKISKYMDRAEN	ubiquitination	[1]
87	DQEKEDGKYHKQIKI	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex. 

Sequence Annotation

 DOMAIN 8 86 MIT.
 REGION 168 231 Important for association with membranes.  

Keyword

 3D-structure; Cell cycle; Cell division; Complete proteome; Endosome; Membrane; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 249 AA 

Protein Sequence

Gene Ontology

 GO:0019898; C:extrinsic to membrane; IDA:UniProtKB.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
 GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
 GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
 GO:0000920; P:cytokinetic cell separation; IMP:UniProtKB.
 GO:0000281; P:mitotic cytokinesis; IMP:UniProtKB.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 

Interpro

 IPR007330; MIT. 

Pfam

 PF04212; MIT 

SMART

 SM00745; MIT 

PROSITE

  

PRINTS