UniProt Accession

 GLRX3_ECOLI; P0AC62; P37687; Q2M7S4 

Genbank Protein ID

 U00039; U00096; AP009048 

Genbank Nucleotide ID

 AAB18587.1; AAC76634.1; BAE77682.1 

Protein Name

 Glutaredoxin-3 

Protein Synonyms/Alias

 Grx3 

Gene Name

 grxC 

Gene Synonyms/Alias

 yibM; b3610; JW3585 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
9	ANVEIYTKETCPYCH	acetylation	[1, 2]
40	PIDGNAAKREEMIKR	acetylation	[2]
46	AKREEMIKRSGRTTV	acetylation	[1, 2]

Reference

 [1] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [2] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfide bonds in a coupled system with glutathione reductase. 

Sequence Annotation

 DOMAIN 2 83 Glutaredoxin.
 DISULFID 12 15 Redox-active (By similarity).  

Keyword

 3D-structure; Complete proteome; Deoxyribonucleotide synthesis; Direct protein sequencing; Disulfide bond; Electron transport; Redox-active center; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 83 AA 

Protein Sequence

Gene Ontology

 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0043295; F:glutathione binding; IDA:EcoCyc.
 GO:0015035; F:protein disulfide oxidoreductase activity; IDA:EcoCyc.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0009263; P:deoxyribonucleotide biosynthetic process; IEA:UniProtKB-KW.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW. 

Interpro

 IPR011767; GLR_AS.
 IPR002109; Glutaredoxin.
 IPR014025; Glutaredoxin_subgr.
 IPR011900; GRX_bact.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00462; Glutaredoxin 

SMART

  

PROSITE

 PS00195; GLUTAREDOXIN_1
 PS51354; GLUTAREDOXIN_2 

PRINTS

 PR00160; GLUTAREDOXIN.