UniProt Accession

 IMDH1_HUMAN; P20839; A4D0Z6; A4D0Z7; A6NDW5; A6NNI6; B3KNP7; B3KVM8; B4DE09; C9JV30; J3KNX8; Q8N194; Q96NU2 

Genbank Protein ID

 J05272; AK054640; AK054667; AK122994; AK293413; AC010655; CH236947; CH236947; CH471070; BC033622; CD014008 

Genbank Nucleotide ID

 AAA36114.1; BAB70780.1; BAG51409.1; BAG53840.1; BAG56920.1; EAL24310.1; EAL24311.1; EAW83652.1; AAH33622.2 

Protein Name

 Inosine-5'-monophosphate dehydrogenase 1 

Protein Synonyms/Alias

 IMP dehydrogenase 1; IMPD 1; IMPDH 1; IMPDH-I 

Gene Name

 IMPDH1 

Gene Synonyms/Alias

 IMPD1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
134	VGDVLEAKMRHGFSG	ubiquitination	[1, 2]
169	DIDFLAEKDHTTLLS	ubiquitination	[3]
195	APAGVTLKEANEILQ	ubiquitination	[3]
205	NEILQRSKKGKLPIV	ubiquitination	[3]
206	EILQRSKKGKLPIVN	ubiquitination	[3]
208	LQRSKKGKLPIVNDC	ubiquitination	[3]
238	RDYPLASKDSQKQLL	ubiquitination	[2]
242	LASKDSQKQLLCGAA	ubiquitination	[1, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. 

Sequence Annotation

 DOMAIN 114 173 CBS 1.
 DOMAIN 179 237 CBS 2.
 NP_BIND 274 276 NAD (By similarity).
 NP_BIND 324 326 NAD (By similarity).
 REGION 364 366 IMP binding.
 REGION 387 388 IMP binding.
 REGION 411 415 IMP binding (By similarity).
 ACT_SITE 331 331 Thioimidate intermediate (By similarity).
 METAL 326 326 Potassium; via carbonyl oxygen (By
 METAL 328 328 Potassium; via carbonyl oxygen (By
 METAL 331 331 Potassium; via carbonyl oxygen (By
 METAL 500 500 Potassium; via carbonyl oxygen; shared
 METAL 501 501 Potassium; via carbonyl oxygen; shared
 METAL 502 502 Potassium; via carbonyl oxygen; shared
 BINDING 329 329 IMP.
 BINDING 441 441 IMP (By similarity).  

Keyword

 3D-structure; Alternative splicing; CBS domain; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; DNA-binding; GMP biosynthesis; Leber congenital amaurosis; Metal-binding; NAD; Nucleus; Oxidoreductase; Potassium; Purine biosynthesis; Reference proteome; Repeat; Retinitis pigmentosa; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 514 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IDA:UniProtKB.
 GO:0003938; F:IMP dehydrogenase activity; TAS:ProtInc.
 GO:0046872; F:metal ion binding; IEA:HAMAP.
 GO:0000166; F:nucleotide binding; IEA:HAMAP.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006177; P:GMP biosynthetic process; IEA:HAMAP.
 GO:0006144; P:purine nucleobase metabolic process; TAS:Reactome.
 GO:0009168; P:purine ribonucleoside monophosphate biosynthetic process; TAS:Reactome. 

Interpro

 IPR013785; Aldolase_TIM.
 IPR000644; Cysta_beta_synth_core.
 IPR005990; IMP_DH.
 IPR015875; IMP_DH/GMP_Rdtase_CS.
 IPR001093; IMP_DH_GMPRt. 

Pfam

 PF00571; CBS
 PF00478; IMPDH 

SMART

 SM00116; CBS 

PROSITE

 PS51371; CBS
 PS00487; IMP_DH_GMP_RED 

PRINTS