| Tag | Content |
|---|
| CPLM ID | CPLM-011659 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Retinoblastoma-like protein 2 |
Protein Synonyms/Alias | 130 kDa retinoblastoma-associated protein; p130; Retinoblastoma-related protein 2; RBR-2; pRb2 |
Gene Name | RBL2 |
Gene Synonyms/Alias | RB2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 384 | TAERVQMKNILQQHF | ubiquitination | [1, 2] |
|
Reference | [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [ PMID: 21890473] [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties. Chen Z, Zhou Y, Song J, Zhang Z. Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [ PMID: 23603789] |
Functional Description | Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. |
Sequence Annotation | REGION 417 1024 Pocket; binds E1A.
REGION 417 616 Domain A.
REGION 617 827 Spacer.
REGION 828 1024 Domain B.
MOD_RES 413 413 Phosphoserine (By similarity).
MOD_RES 417 417 Phosphothreonine (By similarity).
MOD_RES 639 639 Phosphoserine.
MOD_RES 642 642 Phosphothreonine (By similarity).
MOD_RES 662 662 Phosphoserine.
MOD_RES 672 672 Phosphoserine.
MOD_RES 948 948 Phosphoserine (By similarity).
MOD_RES 952 952 Phosphoserine.
MOD_RES 966 966 Phosphoserine.
MOD_RES 971 971 Phosphoserine (Probable).
MOD_RES 972 972 Phosphoserine (Probable).
MOD_RES 973 973 Phosphoserine (Probable).
MOD_RES 974 974 Phosphothreonine (Probable).
MOD_RES 981 981 Phosphoserine (Probable).
MOD_RES 982 982 Phosphoserine.
MOD_RES 986 986 Phosphothreonine.
MOD_RES 1035 1035 Phosphoserine. |
Keyword | Cell cycle; Chromatin regulator; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repressor; Transcription; Transcription regulation; Tumor suppressor. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1139 AA |
Protein Sequence | MPSGGDQSPP PPPPPPAAAA SDEEEEDDGE AEDAAPPAES PTPQIQQRFD ELCSRLNMDE 60
AARAEAWDSY RSMSESYTLE GNDLHWLACA LYVACRKSVP TVSKGTVEGN YVSLTRILKC 120
SEQSLIEFFN KMKKWEDMAN LPPHFRERTE RLERNFTVSA VIFKKYEPIF QDIFKYPQEE 180
QPRQQRGRKQ RRQPCTVSEI FHFCWVLFIY AKGNFPMISD DLVNSYHLLL CALDLVYGNA 240
LQCSNRKELV NPNFKGLSED FHAKDSKPSS DPPCIIEKLC SLHDGLVLEA KGIKEHFWKP 300
YIRKLYEKKL LKGKEENLTG FLEPGNFGES FKAINKAYEE YVLSVGNLDE RIFLGEDAEE 360
EIGTLSRCLN AGSGTETAER VQMKNILQQH FDKSKALRIS TPLTGVRYIK ENSPCVTPVS 420
TATHSLSRLH TMLTGLRNAP SEKLEQILRT CSRDPTQAIA NRLKEMFEIY SQHFQPDEDF 480
SNCAKEIASK HFRFAEMLYY KVLESVIEQE QKRLGDMDLS GILEQDAFHR SLLACCLEVV 540
TFSYKPPGNF PFITEIFDVP LYHFYKVIEV FIRAEDGLCR EVVKHLNQIE EQILDHLAWK 600
PESPLWEKIR DNENRVPTCE EVMPPQNLER ADEICIAGSP LTPRRVTEVR ADTGGLGRSI 660
TSPTTLYDRY SSPPASTTRR RLFVENDSPS DGGTPGRMPP QPLVNAVPVQ NVSGETVSVT 720
PVPGQTLVTM ATATVTANNG QTVTIPVQGI ANENGGITFF PVQVNVGGQA QAVTGSIQPL 780
SAQALAGSLS SQQVTGTTLQ VPGQVAIQQI SPGGQQQKQG QSVTSSSNRP RKTSSLSLFF 840
RKVYHLAAVR LRDLCAKLDI SDELRKKIWT CFEFSIIQCP ELMMDRHLDQ LLMCAIYVMA 900
KVTKEDKSFQ NIMRCYRTQP QARSQVYRSV LIKGKRKRRN SGSSDSRSHQ NSPTELNKDR 960
TSRDSSPVMR SSSTLPVPQP SSAPPTPTRL TGANSDMEEE ERGDLIQFYN NIYIKQIKTF 1020
AMKYSQANMD APPLSPYPFV RTGSPRRIQL SQNHPVYISP HKNETMLSPR EKIFYYFSNS 1080
PSKRLREINS MIRTGETPTK KRGILLEDGS ESPAKRICPE NHSALLRRLQ DVANDRGSH 1139 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:HPA. GO:0005730; C:nucleolus; IDA:HPA. GO:0005654; C:nucleoplasm; TAS:Reactome. GO:0005667; C:transcription factor complex; IEA:Compara. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0016568; P:chromatin modification; IEA:UniProtKB-KW. GO:0000278; P:mitotic cell cycle; TAS:Reactome. GO:0051726; P:regulation of cell cycle; IEA:InterPro. GO:0043550; P:regulation of lipid kinase activity; IDA:UniProtKB. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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