| Tag | Content |
|---|
| CPLM ID | CPLM-002607 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transcriptional factor SWI5 |
Protein Synonyms/Alias | |
Gene Name | SWI5 |
Gene Synonyms/Alias | YDR146C; YD8358.03C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 161 | NLLSTINKSEINKGF | acetylation | [1] | | 227 | GPQFLSPKRKISPAS | ubiquitination | [2] | | 644 | KYENVVIKRSPRKRG | ubiquitination | [2] |
|
Reference | [1] Preparative peptide isoelectric focusing as a tool for improving the identification of lysine-acetylated peptides from complex mixtures. Xie H, Bandhakavi S, Roe MR, Griffin TJ. J Proteome Res. 2007 May;6(5):2019-26. [ PMID: 17397211] [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Determines the mother-cell-specific transcription of the HO endonuclease gene that is responsible for the initiation of mating-type switching in yeast. Recognizes a specific sequence in the promoter of the HO gene. Activates EGT2 transcription in a concentration-dependent manner. Synthesized during G2 and early mitosis. |
Sequence Annotation | ZN_FING 550 574 C2H2-type 1.
ZN_FING 580 604 C2H2-type 2.
ZN_FING 609 632 C2H2-type 3.
DNA_BIND 647 659 A.T hook.
MOTIF 635 659 Nuclear localization signal (Potential).
MOD_RES 225 225 Phosphoserine.
MOD_RES 278 278 Phosphoserine.
MOD_RES 300 300 Phosphoserine.
MOD_RES 339 339 Phosphothreonine.
MOD_RES 376 376 Phosphoserine.
MOD_RES 488 488 Phosphoserine.
MOD_RES 492 492 Phosphoserine.
MOD_RES 505 505 Phosphoserine.
MOD_RES 522 522 Phosphoserine; by CDC28.
MOD_RES 646 646 Phosphoserine; by CDC28.
MOD_RES 664 664 Phosphoserine; by CDC28. |
Keyword | 3D-structure; Activator; Complete proteome; Cytoplasm; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 709 AA |
Protein Sequence | MDTSNSWFDA SKVQSLNFDL QTNSYYSNAR GSDPSSYAIE GEYKTLATDD LGNILNLNYG 60
ETNEVIMNEI NDLNLPLGPL SDEKSVKVST FSELIGNDWQ SMNFDLENNS REVTLNATSL 120
LNENRLNQDS GMTVYQKTMS DKPHDEKKIS MADNLLSTIN KSEINKGFDR NLGELLLQQQ 180
QELREQLRAQ QEANKKLELE LKQTQYKQQQ LQATLENSDG PQFLSPKRKI SPASENVEDV 240
YANSLSPMIS PPMSNTSFTG SPSRRNNRQK YCLQRKNSSG TVGPLCFQEL NEGFNDSLIS 300
PKKIRSNPNE NLSSKTKFIT PFTPKSRVSS ATSNSANITP NNLRLDFKIN VEDQESEYSE 360
KPLGLGIELL GKPGPSPTKS VSLKSASVDI MPTIPGSVNN TPSVNKVSLS SSYIDQYTPR 420
GKQLHFSSIS ENALGINAAT PHLKPPSQQA RHREGVFNDL DPNVLTKNTD NEGDDNEENE 480
PESRFVISET PSPVLKSQSK YEGRSPQFGT HIKEINTYTT NSPSKITRKL TTLPRGSIDK 540
YVKEMPDKTF ECLFPGCTKT FKRRYNIRSH IQTHLEDRPY SCDHPGCDKA FVRNHDLIRH 600
KKSHQEKAYA CPCGKKFNRE DALVVHRSRM ICSGGKKYEN VVIKRSPRKR GRPRKDGTSS 660
VSSSPIKENI NKDHNGQLMF KLEDQLRRER SYDGNGTGIM VSPMKTNQR 709 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:SGD. GO:0005634; C:nucleus; IDA:SGD. GO:0036033; F:mediator complex binding; IMP:SGD. GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IDA:SGD. GO:0001133; F:sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity; IMP:SGD. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0031496; P:positive regulation of mating type switching; IMP:SGD. GO:0007074; P:positive regulation of transcription on exit from mitosis, from RNA polymerase II promoter; IMP:SGD. GO:0000114; P:regulation of transcription involved in G1 phase of mitotic cell cycle; IMP:SGD. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |