UniProt Accession

 ATG5_HUMAN; Q9H1Y0; O60875; Q5JVR2; Q68DI4; Q9H2B8; Q9HCZ7 

Genbank Protein ID

 Y11588; AF293841; CR749386; AL022067; AL133509; AL138917; AL022067; AL133509; AL138917; AL133509; AL022067; AL138917; AL133509; AL022067; AL138917; AL138917; AL133509; AL022067; AL138917; AL022067; AL133509; BC002699; BC093011 

Genbank Nucleotide ID

 CAA72327.1; AAG44955.1; CAH18236.1; CAI42297.1; CAI42297.1; CAI42297.1; CAI42298.1; CAI42298.1; CAI42298.1; CAC19459.2; CAC19459.2; CAC19459.2; CAI42831.1; CAI42831.1; CAI42831.1; CAI20313.1; CAI20313.1; CAI20313.1; CAI20314.1; CAI20314.1; CAI20314.1; AAH02699.1; AAH93011.1 

Protein Name

 Autophagy protein 5 

Protein Synonyms/Alias

 APG5-like; Apoptosis-specific protein 

Gene Name

 ATG5 

Gene Synonyms/Alias

 APG5L; ASP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
5	***MTDDKDVLRDVW	ubiquitination	[1]
138	EADALKHKSQVINEM	ubiquitination	[2]
171	QFWAINRKLMEYPAE	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity). 

Sequence Annotation

 CROSSLNK 130 130 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Alternative splicing; Apoptosis; Autophagy; Complete proteome; Cytoplasm; Isopeptide bond; Polymorphism; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 275 AA 

Protein Sequence

Gene Ontology

 GO:0005776; C:autophagic vacuole; IDA:MGI.
 GO:0034045; C:pre-autophagosomal structure membrane; ISS:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0000045; P:autophagic vacuole assembly; ISS:UniProtKB.
 GO:0001974; P:blood vessel remodeling; IEA:Compara.
 GO:0060047; P:heart contraction; IEA:Compara.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0031397; P:negative regulation of protein ubiquitination; IEA:Compara.
 GO:0032480; P:negative regulation of type I interferon production; TAS:Reactome.
 GO:0048840; P:otolith development; IEA:Compara.
 GO:0043687; P:post-translational protein modification; ISS:UniProtKB.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0042311; P:vasodilation; IEA:Compara.
 GO:0055015; P:ventricular cardiac muscle cell development; IEA:Compara. 

Interpro

 IPR007239; Atg5. 

Pfam

 PF04106; APG5 

SMART

  

PROSITE

  

PRINTS