UniProt Accession

 A8MWH4_HUMAN; A8MWH4 

Genbank Protein ID

 AC026461 

Genbank Nucleotide ID

  

Protein Name

 Metallothionein 

Protein Synonyms/Alias

  

Gene Name

 MT1F 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
23	CAGSCKCKECKCTSC	ubiquitination	[1]
26	SCKCKECKCTSCKKS	ubiquitination	[1]
32	CKCTSCKKSCCSCCP	ubiquitination	[1]
52	CAQGCVCKGASEKCS	ubiquitination	[2]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Metallothioneins have a high content of cysteine residues that bind various heavy metals (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Metal-binding; Metal-thiolate cluster; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 62 AA 

Protein Sequence

Gene Ontology

 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. 

Interpro

 IPR017854; Metalthion_dom.
 IPR023587; Metalthion_dom_vert.
 IPR003019; Metalthion_sfam_euk.
 IPR000006; Metalthion_vert.
 IPR018064; Metalthion_vert_metal_BS. 

Pfam

 PF00131; Metallothio 

SMART

  

PROSITE

 PS00203; METALLOTHIONEIN_VRT 

PRINTS

 PR00860; MTVERTEBRATE.