CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034281
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Transient receptor potential cation channel subfamily V member 4 
Protein Synonyms/Alias
  
Gene Name
 Trpv4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
177LSFLLTHKKRLTDEEubiquitination[1]
192FREPSTGKTCLPKALubiquitination[1]
197TGKTCLPKALLNLSNubiquitination[1]
297ENTKFVTKMYDLLLLubiquitination[1]
305MYDLLLLKCSRLFPDubiquitination[1]
659GEMVTVGKSSDGTPDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ANK repeat; Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 764 AA 
Protein Sequence
MADPGDGPRA APGEVAEPPG DESGTSGGEA FPLSSLANLF EGEEGSSSLS PVDASRPAGP 60
GDGRPNLRMK FQGAFRKGVP NPIDLLESTL YESSVVPGPK KAPMDSLFDY GTYRHHPSDN 120
KRWRRKVVEK QPQSPKAPAP QPPPILKVFN RPILFDIVSR GSTADLDGLL SFLLTHKKRL 180
TDEEFREPST GKTCLPKALL NLSNGRNDTI PVLLDIAERT GNMREFINSP FRDIYYRGEL 240
PLSLAACTNQ PHIVNYLTEN PHKKADMRRQ DSRGNTVLHA LVAIADNTRE NTKFVTKMYD 300
LLLLKCSRLF PDSNLETVLN NDGLSPLMMA AKTGKIGNRH EMLAVEPINE LLRDKWRKFG 360
AVSFYINVVS YLCAMVIFTL TAYYQPLEGT PPYPYRTTVD YLRLAGEVIT LFTGVLFFFT 420
SIKDLFTKKC PGVNSLFVDG SFQLLYFIYS VLVVVSAALY LAGIEAYLAV MVFALVLGWM 480
NALYFTRGLK LTGTYSIMIQ KILFKDLFRF LLVYLLFMIG YASALVTLLN PCTNMKVCDE 540
DQSNCTVPTY PACRDSETFS AFLLDLFKLT IGMGDLEMLS SAKYPVVFIL LLVTYIILTF 600
VLLLNMLIAL MGETVGQVSK ESKHIWKLQW ATTILDIERS FPVFLRKAFR SGEMVTVGKS 660
SDGTPDRRWC FRVDEVNWSH WNQNLGIINE DPGKSEIYQY YGFSHTVGRL RRDRWSSVVP 720
RVVELNKNSS ADEVVVPLDN LGNPNCDGHQ QGYAPKWRTD DAPL 764 
Gene Ontology
 GO:0005929; C:cilium; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0005262; F:calcium channel activity; IDA:MGI.
 GO:0005034; F:osmosensor activity; IDA:MGI.
 GO:0042538; P:hyperosmotic salinity response; IMP:MGI.
 GO:0007231; P:osmosensory signaling pathway; IDA:MGI.
 GO:0047484; P:regulation of response to osmotic stress; IMP:MGI.
 GO:0030103; P:vasopressin secretion; IMP:MGI. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR005821; Ion_trans_dom.
 IPR008347; TRPV1-4_channel.
 IPR008348; TRPV4_channel.
 IPR024862; TRPV_channel. 
Pfam
 PF00520; Ion_trans 
SMART
 SM00248; ANK 
PROSITE
  
PRINTS
 PR01768; TRPVRECEPTOR.
 PR01769; VRL2RECEPTOR.