UniProt Accession

 TRMB_DROME; O77263; Q9W527 

Genbank Protein ID

 AE014298; AL031765; AY094742 

Genbank Nucleotide ID

 AAF45720.2; CAA21130.1; AAM11095.1 

Protein Name

 tRNA (guanine-N(7)-)-methyltransferase 

Protein Synonyms/Alias

 tRNA (guanine(46)-N(7))-methyltransferase; tRNA(m7G46)-methyltransferase 

Gene Name

 CG4045 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
240	QSSEEGAKVVRNKGD	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity). 

Sequence Annotation

 REGION 102 103 S-adenosyl-L-methionine binding (By
 REGION 137 138 S-adenosyl-L-methionine binding (By
 REGION 235 237 S-adenosyl-L-methionine binding (By
 ACT_SITE 160 160 By similarity.
 BINDING 79 79 S-adenosyl-L-methionine; via carbonyl
 BINDING 157 157 S-adenosyl-L-methionine; via carbonyl  

Keyword

 Complete proteome; Methyltransferase; Nucleus; Reference proteome; RNA-binding; S-adenosyl-L-methionine; Transferase; tRNA processing; tRNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 256 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0008176; F:tRNA (guanine-N7-)-methyltransferase activity; IEA:EC.
 GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
 GO:0036265; P:RNA (guanine-N7)-methylation; ISS:GOC.
 GO:0006400; P:tRNA modification; ISS:UniProtKB. 

Interpro

 IPR003358; tRNA_(Gua-N-7)_MeTrfase.
 IPR025763; tRNA_(Gua-N-7)_MeTrfase_euk. 

Pfam

 PF02390; Methyltransf_4 

SMART

  

PROSITE

  

PRINTS